59724-61-7

Basic information

• Product Name: N-2-Hydroxyethyl-N-Methyl-
• Synonyms: N-2-Hydroxyethyl-N-Methyl-;N-(2-hydroxyethyl)-N,4-dimethylbenzenesulfonamide
• CAS NO: 59724-61-7
• Molecular Formula: C₁₀H₁₅NO₃S
• Molecular Weight: 229.296
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 59724-61-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.2°Cat760mmHg
• Flash Point: 181.9°C
• Appearance: /
• Density: 1.237g/cm³
• Vapor Pressure: 2.32E-06mmHg at 25°C
• Refractive Index: 1.555
• PKA: 14.29±0.10(Predicted)
• CAS DataBase Reference: N-2-Hydroxyethyl-N-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-Hydroxyethyl-N-Methyl-(59724-61-7)
• EPA Substance Registry System: N-2-Hydroxyethyl-N-Methyl-(59724-61-7)

Safety Data

• Hazardous Substances Data: 59724-61-7(Hazardous Substances Data)

Usage

Description

N-2-Hydroxyethyl-N-Methyl-p-toluenesulfonamide, also known as N-2-Hydroxyethyl-N-Methyl-, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals. It is characterized by its ability to form derivatives with potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
N-2-Hydroxyethyl-N-Methylis used as a key intermediate for the preparation of Rosiglitazone (R693500) derivatives, which are known for their antidiabetic properties. These derivatives help in managing blood sugar levels and are particularly useful for patients with type 2 diabetes.

InChI:InChI=1/C10H15NO3S/c1-9-3-5-10(6-4-9)15(13,14)11(2)7-8-12/h3-6,12H,7-8H2,1-2H3

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 107-07-3 2-chloro-ethanol 
• 640-61-9 N-methyl-p-toluenesulfonylamide 

Downstream Products

• 1394916-91-6 N-(2-([1,1'-biphenyl]-4-yloxy)ethyl)-N,4-dimethylbenzenesulfonamide 
• 1017676-67-3 N-methyl-N-p-toluenesulfonylethylenediamine 
• 66821-81-6 N-methyl-N,N'-bis(p-toluenesulfonyl)ethylenediamine 
• 1026284-53-6 N-methyl-N-p-toluenesulfonylaminoethyl methanesulfonate 

Relevant articles and documents

Electrosynthesis of Arylsulfonamides from Amines and Sodium Sulfinates Using H2O-NaI as the Electrolyte Solution at Room Temperature

With H2O as the solvent and NaI as the supporting electrolyte, a green and efficient electrochemical route has been developed to synthesize arylsulfonamides via I2electrogenerated in situ at a graphite anode to promote the reaction of sodium sulfinates with aromatic or aliphatic primary and secondary amines. The target products could be obtained in good to excellent yields at room temperature.

Copper-catalyzed sulfonamides formation from sodium sulfinates and amines

A new and convenient method for the construction of sulfonamides via a copper-catalyzed oxidative coupling between sodium sulfinates and amines with 1 atm O2 or DMSO as the oxidant was described. This method provides efficient and robust synthesis of functional sulfonamides in good yields and excellent chemoselectivity. And detailed mechanistic studies showed that this transformation may go through a single electron transfer (SET) pathway.