598-81-2

Basic information

• Product Name: (R)-(+)-Lactamide
• Synonyms: (R)-(+)-2-HYDROXYPROPIONAMIDE;(R)-(+)-LACTAMIDE;(R)-2-hydroxypropanamide;R-(+)-Lactamide 97+% cp 98+% ee;(2R)-2-Hydroxypropanamide;D-Lactamide;(R)-(+)-Lactamide 97%;(R)-(+)-Lactamide, 98%, ee: 99%
• CAS NO: 598-81-2
• Molecular Formula: C₃H₇NO₂
• Molecular Weight: 89.09
• Product Categories: Amides;Chiral Building Blocks;Organic Building Blocks
• Mol File: 598-81-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 50-53 °C(lit.)
• Boiling Point: 281.9 °C at 760 mmHg
• Flash Point: 124.3 °C
• Appearance: /
• Density: 1.161 g/cm³
• Vapor Pressure: 0.000409mmHg at 25°C
• Refractive Index: 20.5 ° (C=10, H2O)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.34±0.20(Predicted)
• CAS DataBase Reference: (R)-(+)-Lactamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-Lactamide(598-81-2)
• EPA Substance Registry System: (R)-(+)-Lactamide(598-81-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 24/25-45-36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 598-81-2(Hazardous Substances Data)

Usage

General Description

(R)-(+)-Lactamide, also known as (R)-2-Pyrrolidone, is a chiral amide compound that is primarily used as a precursor for the synthesis of various pharmaceuticals and fine chemicals. It is a white crystalline solid with a mild, characteristic odor, and it is soluble in water, alcohol, and ether. (R)-(+)-Lactamide is used as a building block in the production of agrochemicals, pharmaceuticals, and polymers. It is also used as a solvent and as an intermediate in the production of active pharmaceutical ingredients. The compound is considered to be of low toxicity and has been used in various applications in the chemical industry.

InChI:InChI=1/C3H7NO2/c1-2(5)3(4)6/h2,5H,1H3,(H2,4,6)/t2-/m1/s1

Upstream product

• 617-57-2 2-(2-hydroxy-1-oxopropoxy)propionic acid 
• 78-97-7 2-hydroxy-propionitrile 
• 7664-41-7 ammonia 
• 95-96-5 D,L-lactide 
• 13372-32-2 5-methyl-4-oxo-1,3-dioxolane 
• 4158-85-4 2,2,5-trimethyl-1,3-dioxolan-4-one 
• 52046-55-6 2,N-dihydroxy-propionamidine 
• 7782-77-6 cis-nitrous acid 
• 60-29-7 diethyl ether 
• 23427-66-9 2-benzoyloxy-propionic acid amide 
• 201230-82-2 carbon monoxide 
• 91-22-5 quinoline 
• 17392-83-5 (R)-Methyl lactate 
• 849585-22-4 LACTIC ACID 

Downstream Products

• 6336-49-8 lactic acid hydroxymethylamide 
• 16400-62-7 2-n-Hexyl-5-methyl-oxazol 
• 539-08-2 p-Lactophenetide 
• 107-13-1 acrylonitrile 
• 57-13-6 urea 
• 41249-43-8 8-benzyl-2-methyl-1-oxa-4,8-diaza-spiro[4.5]decan-3-one 
• 42463-59-2 5c-methyl-2r-phenyl-oxazolidin-4-one 
• 42463-59-2 5t-methyl-2r-phenyl-oxazolidin-4-one 
• 65298-12-6 2r-(3,5-dichloro-phenyl)-5c-methyl-oxazolidin-4-one 
• 65298-12-6 2r-(3,5-dichloro-phenyl)-5t-methyl-oxazolidin-4-one 
• 65298-18-2 2r-(1-chloro-2-phenyl-vinyl)-5c-methyl-oxazolidin-4-one 
• 65298-18-2 2r-(1-chloro-2-phenyl-vinyl)-5t-methyl-oxazolidin-4-one 
• 63353-84-4 2-(4-chloro-2-methyl-phenoxymethyl)-5-methyl-oxazolidin-4-one 
• 63353-84-4 2-(4-chloro-2-methyl-phenoxymethyl)-5-methyl-oxazolidin-4-one 

Relevant articles and documents

Unusual ammonolysis of a secondary amide assisted by unsubstituted vicinal amide group

Evidence for the participation of neighboring -CONH2 group in the ammonolysis of disubstituted amide was obtained. The surprising conversion of 1 into 3 in very mild conditions is a process formed by two consecutive first order reactions. Kinetics were performed in ethanol at various temperatures and NH3 concentrations. The ammonolysis of the isolated intermediate 2 allowed the unambiguous attribution of k1 and k2 to steps 1 → 2 and 2 → 3, respectively. The thermodynamic parameters of activation for both steps of the process were evaluated.

Catalyst, preparation method thereof and preparation method of amide compound

The invention relates to a catalyst, a preparation method thereof, and a preparation method for hydrating nitrile groups into amides. The catalyst is used for catalyzing nitrile groups to be hydratedinto amides, and the structural general formula of the catalyst is shown in the specification. In the formula, a plurality of R are respectively and independently ones selected from aromatic groups, heteroaromatic groups and non-aromatic ring groups; a plurality of R are ones respectively and independently selected from linear alkyl groups and alkane aromatic groups; X is one selected from Cl and Br; and L is one selected from OTf, BF4, PF6 and SbF6. The catalyst can catalyze nitrile groups to be hydrated into amides, and the nitrile groups can be catalyzed to be hydrated into amides even at a low temperature (20-80 DEG C); besides, compared with existing common catalysts for catalyzing nitrile groups to be hydrated into amides, the catalyst has the advantages that the equivalent weight of the catalyst can be obviously reduced, and nitrile groups can reach a relatively high conversion rate when the equivalent weight of the catalyst is only 0.01 mol%-0.5 mol%; and meanwhile, the catalyst is wider in application range and can catalyze various nitrile compounds to be hydrated into amide compounds.

Promotion of catalytic properties of vanillin loaded MCM-41 by Cu(I) and Cu(II) for enhanced removal of quinoline contaminants

In the present study, to enhance removal of quinoline contaminants using natural active component, vanillin was loaded onto the MCM-41 (Mobile Component Material) nanoparticles in a simple way. The product was divided into two parts, which were improved by Copper(I) and Copper(II) salts. Promoted synthetic nanocatalysts (Cu(I)/Van./MCM-41, and Cu(II)/Van./MCM-41) were characterized using X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Energy-Dispersive X-Ray Spectroscopy (EDS), Mapping, Fourier-Transform Infrared Spectroscopy (FTIR), and BET/BJH (Brunauer-Emmett-Teller (BET) and Barret-Joyner-Halenda (BJH)) techniques. To reach optimal conditions, experimental design was performed using Response Surface Methodology (RSM). The experiments were done with the aid of nanocomposites, in presence of ultraviolet radiation without any auxiliary oxidants. Degradation percentages were measured by an Ultraviolet (UV) spectrophotometer. The products were identified using Gas Chromatography–Mass (GC-Mass) technique, and some mechanisms for quinoline removal were proposed. The results indicated that Cu (I) showed better performance in enhanced removal of quinoline than Cu(II).