60071-69-4Relevant articles and documents
Design, synthesis and molecular docking of novel structural hybrids of substituted isatin based pyrazoline and thiadiazoline as antitumor agents
Gangarapu, Kiran,Thumma, Gouthami,Manda, Sarangapani,Jallapally, Anvesh,Jarapula, Ravi,Rekulapally, Sriram
, p. 819 - 829 (2017/03/06)
Cancer, which is considered to be the world’s most serious illness cause 8.2 million deaths and this rate may double by 2030. We herein report a new series of 3-(2-(p-substituted)-2-((5-phenyl-1,3,4-thiadiazol-2-yl)imino)-2-(p-substituted)ethylidene)indolin-2-one (15–19) and 5-substituted-5′-substituted phenyl-2′,4′-dihydrospiro[indoline-3,3′-pyrazol]-2-one derivatives (20–24) as potent anticancer agents. These compounds were evaluated for in vitro antitumor activity against the National Cancer Institute panel of 60 cancer cell lines. Among all the synthesized compounds, two compounds 15 and 16 showed remarkable antitumor activity with GI50 (MG-MID) values of 0.65 & 0.72 μM, respectively against Non-small cell lung cancer. To gain insight for mode of binding with Epidermal Growth Factor Receptor kinase enzyme, these compounds were further subjected to docking studies.
Synthesis of spiro heterocyclic compounds
Ibrahim, Mohamed N.,El-Messmary, Mohamed F.,Elarfi, Mohamed G.A.
experimental part, p. 55 - 58 (2011/01/03)
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea
Synthesis of Spiro Indolin-2-one Derivatives
El-Ahl, Abdel Asis S.,Afeefy, Hussein,Metwally, Mohamed Abbas
, p. 201 - 222 (2007/10/02)
The reactions of active methylene compounds and hydrazine with (2-oxoindolin-3-ylidene)-malononitrile and -acetophenone in ethanol/piperidine have been studied.Both substances gave Michael-type adducts followed by cyclization.The structures of the products were determined from the results of elemental analysis, IR, 1H-NMR and mass spectra.
