6011-63-8

Basic information

• Product Name: [3,3'-Bi-2H-indole]-2,2'-dione,1,1',3,3'-tetrahydro- 3-hydroxy-
• Synonyms: 3-hydroxy-3,3'-biindoline-2,2'-dione;3-hydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione;3-Hydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dion
• CAS NO: 6011-63-8
• Molecular Formula: C16H12N2O3
• Molecular Weight: 280.283
• Mol File: 6011-63-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [3,3'-Bi-2H-indole]-2,2'-dione,1,1',3,3'-tetrahydro- 3-hydroxy- (CAS DataBase Reference)
• NIST Chemistry Reference: [3,3'-Bi-2H-indole]-2,2'-dione,1,1',3,3'-tetrahydro- 3-hydroxy- (6011-63-8)
• EPA Substance Registry System: [3,3'-Bi-2H-indole]-2,2'-dione,1,1',3,3'-tetrahydro- 3-hydroxy- (6011-63-8)

Safety Data

• Hazardous Substances Data: 6011-63-8(Hazardous Substances Data)

Upstream product

• 59-48-3 2-oxoindole 
• 16990-73-1 2-Hydroxyindole 
• 476-34-6 isoindigo 
• 464-73-3 3,3'-Dihydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 91-56-5 indole-2,3-dione 
• 476-34-6 isoindigo 
• 476-34-6 isoindigo 
• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 

Relevant articles and documents

Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon-carbon double bond formation

The iron-catalyzed cross-dehydrogenative coupling (CDC) of C(sp3)-H/C(sp3)-H bonds to afford olefins by 4H elimination is described. This method employs air (molecular oxygen) as an ideal oxidant, and is performed under mild, ligand-free and base-free conditions. H2O is the only byproduct. Good tolerance of functional groups and high yields have also been achieved. Preliminary mechanistic investigations suggest that the present transformation involves a radical process.

3-Hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one as a versatile intermediate for retro-Henry and Friedel-Crafts alkylation reactions in aqueous medium

The first example of a retro-Henry type reaction is reported using 3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-ones which are prepared via catalyst-free Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin. These compounds were used