614-16-4Relevant articles and documents
Synthesis, ellipsometry and non-linear optical features of substituted 1,3,5-triphenylpyrazolines
Gondek, Ewa,Nizio?, Jacek,Danel, Andrzej,Kucharek, Mateusz,J?dryka, Jaros?aw,Karasiński, Pawe?,Nosidlak, Natalia,Fedorchuk, Andrij A.
, p. 741 - 745 (2019)
Ellipsometric and nonlinear optical properties of new, differently substituted, 1,3,5-triphenylpyrazolines dyes, were studied. Results of theoretical calculation within a framework of density functional theory (DFT) technique were verified by spectroscopic ellipsometry and optical second harmonic generation (SHG) experiment at fundamental laser wavelength 1064 nm. Absorption bands and complex refractive indices were determined. Principal role of 2-thienyl substituent for first order nonlinear optical properties was demonstrated.
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Salvatori
, p. II, 287 (1891)
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One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents
Barghash, Reham F.,Eldehna, Wagdy M.,Kovalová, Markéta,Vojá?ková, Veronika,Kry?tof, Vladimír,Abdel-Aziz, Hatem A.
, (2021/11/04)
In the current study, we report on the development of novel series of pyrazolo[3,4-b]pyridine derivatives (8a-u, 11a-n, and 14a,b) as potential anticancer agents. The prepared pyrazolo[3,4-b]pyridines have been screened for their antitumor activity in vitro at NCI-DTP. Thereafter, compound 8a was qualified by NCI for full panel five-dose assay to assess its GI50, TGI and LC50 values. Compound 8a showed broad-spectrum anti-proliferative activities over the whole NCI panel, with outstanding growth inhibition full panel GI50 (MG-MID) value equals 2.16 μM and subpanel GI50 (MG-MID) range: 1.92–2.86 μM. Furthermore, pyrazolo[3,4-b]pyridines 8a, 8e-h, 8o, 8u, 11a, 11e, 11h, 11l and 14a-b were assayed for their antiproliferative effect against a panel of leukemia cell lines (K562, MV4-11, CEM, RS4;11, ML-2 and KOPN-8) where they possessed moderate to excellent anti-leukemic activity. Moreover, pyrazolo[3,4-b]pyridines 8o, 8u, 14a and 14b were further explored for their effect on cell cycle on RS4;11 cells, in which they dose-dependently increased populations of cells in G2/M phases. Finally we analyzed the changes of selected proteins (HOXA9, MEIS1, PARP, BcL-2 and McL-1) related to cell death and viability in RS4;11 cells via Western blotting. Collectively, the obtained results suggested pyrazolo[3,4-b]pyridines 8o, 8u, 14a and 14b as promising lead molecules for further optimization to develop more potent and efficient anticancer candidates.
Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions
Sharma, Pawan K.,Kumar, Rajiv,Ram, Sita,Chandak, Navneet
supporting information, p. 1847 - 1856 (2021/04/26)
A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.
