615-41-8

Basic information

• Product Name: 1-Chloro-2-iodobenzene
• Synonyms: 1-chloro-2-iodo-benzen;2-Chlorophenyl iodide;2-Iodochlorobenzene;Benzene, 1-chloro-2-iodo-;O-IODOCHLOROBENZENE;O-CHLOROIODOBENZENE;2-CHLORO-1-IODOBENZENE;2-CHLOROIODOBENZENE
• CAS NO: 615-41-8
• Molecular Formula: C₆H₄ClI
• Molecular Weight: 238.45
• EINECS: 210-423-4
• Product Categories: Chlorine Compounds;Iodine Compounds
• Mol File: 615-41-8.mol
• Article Data: 41

Chemical Properties

• Melting Point: 1 °C(lit.)
• Boiling Point: 234-235 °C(lit.)
• Flash Point: 233 °F
• Appearance: Clear slightly yellow/Liquid
• Density: 1.952 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0805mmHg at 25°C
• Refractive Index: n20/D 1.6334(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 0.069g/l
• Water Solubility: INSOLUBLE
• Sensitive: Light Sensitive
• BRN: 1905116
• CAS DataBase Reference: 1-Chloro-2-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-iodobenzene(615-41-8)
• EPA Substance Registry System: 1-Chloro-2-iodobenzene(615-41-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• RIDADR: UN 2810
• WGK Germany: 3
• F: 8
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 615-41-8(Hazardous Substances Data)

Usage

Description

1-Chloro-2-iodobenzene is an organic compound with the chemical formula C6H4ClI, featuring a chlorine atom at the 1st position and an iodine atom at the 2nd position on a benzene ring. It is a clear, colorless to light yellow liquid and is known for its reactivity and use as a building block in the synthesis of various organic compounds.

Uses

1. Used in Pharmaceutical Industry:
1-Chloro-2-iodobenzene is used as a reactant for the synthesis of biaryl derivatives of seasamol, which are known for their antioxidant activity against DPPH radicals. This application is particularly relevant in the development of new drugs and pharmaceutical compounds.
2. Used in Chemical Synthesis:
1-Chloro-2-iodobenzene serves as a precursor in the preparation of various organic compounds, such as 2,2'-dichloro-biphenyl, N,N-diaryl-o-phenylenediamines, and 4(5)-(2-chlorophenyl)-1H-imidazole. These compounds have diverse applications in different industries, including pharmaceuticals, materials science, and chemical research.
3. Used in Material Science:
In the field of material science, 1-chloro-2-iodobenzene is involved in the synthesis of novel compounds with potential applications in various areas, such as electronics, coatings, and polymers.
4. Used in Research and Development:
1-Chloro-2-iodobenzene is also utilized in research and development for the exploration of new chemical reactions and the synthesis of innovative organic compounds with potential applications in various industries.
General Description:
1-Chloro-2-iodobenzene is a versatile organic compound that reacts with lanthanum metal in the presence of trimethylchlorosilane to yield 1-chloro-2-trimethylsilylbenzene, further demonstrating its utility in chemical synthesis and research.

InChI:InChI=1/C6H4ClI/c7-5-3-1-2-4-6(5)8/h1-4H

Upstream product

• 1608-42-0 benzenedizolium-2-carboxylate 
• 15842-76-9 (2-chloro-phenyl)-trimethyl-silane 
• 108-90-7 chlorobenzene 
• 108-95-2 phenol 
• 7553-56-2 iodine 
• 94-36-0 dibenzoyl peroxide 
• 591-50-4 iodobenzene 
• 62-53-3 aniline 
• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 696-62-8 para-iodoanisole 
• 609-65-4 o-chlorobenzoyl chloride 
• 82113-65-3 bis(trifluoromethanesulfonyl)amide 
• 95-51-2 o-chloroaniline 
• 3900-89-8 2-Chlorobenzeneboronic acid 

Downstream Products

• 39655-09-9 2-iodo-2’-methylbiphenyl 
• 122899-23-4 2-<(2-chlorophenyl)thio>pyridine 
• 106920-22-3 1,2-bis(pyridin-2-ylthio)benzene 
• 104014-41-7 1-<2-<(2-Chlorphenyl)amino>phenyl>ethanon 
• 20441-02-5 (2-chloro-phenyl)-diphenylamine 
• 142272-83-1 1-chloro-2-(hex-1-yn-1-yl)benzene 
• 6962-87-4 tris(2-chlorophenyl)phosphorus 
• 21920-61-6 tris(2-chlorophenyl)arsenic 
• 98288-14-3 methyl (2E)-3-(2-chlorophenyl)prop-2-enoate 
• 5293-97-0 2,2'-dichlorobenzophenone 
• 108-90-7 chlorobenzene 
• 118-91-2 ortho-chlorobenzoic acid 
• 13029-08-8 2,2'-Dichlorobiphenyl 
• 208709-90-4 (S)-2-[(S)-2-tert-Butoxycarbonylamino-5-(2-chloro-phenyl)-pent-4-ynoylamino]-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

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Arene diazonium saccharin intermediates: A greener and cost-effective alternative method for the preparation of aryl iodide

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste.

An efficient gram scale synthesis of aryl iodides from aryl diazofluoroborates in water under mild conditions

Transition metal-free synthesis of synthetically valuable aryl iodides from aryl diazofluroborates in water under mild conditions has been described. Majority of synthesized aryl iodides are obtained in quantitative yields (>99%) under present reaction conditions. The structural effects due to the substituents present on aryl diazofluoroborates did not show any satisfactory effect on the yields of the aryl iodides. Hence, the methodology presented here was found to be adventitious for the quantitative production of synthetically valuable aryl iodides.