63405-88-9

Basic information

• Product Name: Benzenemethanol, 4-amino-2-methyl-
• CAS NO: 63405-88-9
• Molecular Formula: C8H11NO
• Mol File: 63405-88-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-amino-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-amino-2-methyl-(63405-88-9)
• EPA Substance Registry System: Benzenemethanol, 4-amino-2-methyl-(63405-88-9)

Safety Data

• Hazardous Substances Data: 63405-88-9(Hazardous Substances Data)

Usage

Physical properties

white to pale yellow crystalline powder, soluble in water and ethanol

Uses

synthesis of pharmaceuticals and organic compounds, intermediate in production of dyes and pigments, manufacturing of fragrances and flavorings

Potential medical use

studied for treatment of certain diseases and conditions

Upstream product

• 99-51-4 4-nitro-o-xylene 
• 61594-81-8 4-amino-2-methylbenzaldehyde 
• 50-00-0 formaldehyd 
• 638-03-9 m-toluidine hydrochloride 

Downstream Products

• 890086-36-9 4-(acetylamino)-2-methylphenyl acetate 
• 838858-88-1 4-(acetylamino)-5-bromo-2-methylbenzyl acetate 
• 838858-87-0 N-[4-(acetyloxymethyl)-2-cyano-5-methylphenyl]-acetamide 

Relevant articles and documents

Chemical development of ZD9331: Synthesis of a bromomethylquinazolinone avoiding a nonselective radical bromination

An efficient regiospecific synthesis of ZD9331 Pivaloyloxymethyl (POM) Bromide (4) has been accomplished via ZD9331 Quinacetate HCl (15) avoiding a nonselective bromination. The original route used a radical bromination on a substrate with three methyl groups, which generated a range of bromomethyl derived compounds that carried through to the final active pharmaceutical ingredient (API). A strategy, based on the Zinin reaction, was developed to synthesize the required bromomethyl compound in a regioselective manner. This approach was successfully scaled to manufacture a tonne of material.