64-72-2 Usage
Description
Chlortetracycline hydrochloride, also known as Aureomycin, is a broad-spectrum antibiotic derived from the Streptomyces aureofaciens substrate. It was the first of the highly successful tetracycline group of antibiotics, discovered by Duggar in 1948. Chlortetracycline hydrochloride is a yellow crystalline powder with a bitter taste and is stable in air but slightly photosensitive. It is soluble in water and slightly soluble in alcohol, with a pH of about 3 when dissolved in water. Chlortetracycline hydrochloride acts as an antimicrobial and antibacterial agent by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Uses
Used in Medicine:
Chlortetracycline hydrochloride is used as an antibiotic for treating various bacterial infections. It exhibits broad-spectrum antibacterial and antiprotozoan activity, making it effective against a wide range of pathogens.
Used in Veterinary Medicine:
Chlortetracycline hydrochloride is used as an antimicrobial and antibacterial agent in veterinary medicine, particularly for treating infections in animals.
Used as an Antiamebic:
Chlortetracycline hydrochloride is used as an antiamebic agent, effective against certain protozoan parasites that cause infections in humans and animals.
Used as a Calcium Chelator:
Chlortetracycline hydrochloride can be used as a calcium chelator, which helps in binding and removing excess calcium ions from biological systems.
Used in Topical and Ophthalmic Applications:
Due to its poor bioavailability and inferior pharmacokinetic properties when taken orally or through parenteral administration, chlortetracycline hydrochloride is still marketed in ointment forms for topical and ophthalmic use, providing localized treatment for infections in the skin and eyes.
Used in Research:
Chlortetracycline hydrochloride is also used in research settings to study the mechanisms of action of tetracycline antibiotics and their effects on bacterial and protozoan pathogens.
Brand Name:
Aureomycin (Lederle) is the brand name under which chlortetracycline hydrochloride was marketed.
Purification Methods
Purify the salt by dissolving 1g rapidly in 20mL of hot water, cooling rapidly to 40o, treating with 0.1mL of 2M HCl, and chilling in an ice-bath. The process is repeated twice. It is also recrystallised from Me2NCHO/Me2CO. [Stephens et al. J Am Chem Soc 76 3568 1954, UV: McCormick et al. J Am Chem Soc 79 2849 1975, Beilstein 14 IV 2631.]
Check Digit Verification of cas no
The CAS Registry Mumber 64-72-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 64-72:
(4*6)+(3*4)+(2*7)+(1*2)=52
52 % 10 = 2
So 64-72-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26-27,31-33H,6,24H2,1-3H3;1H/b20-13-;/t7?,8-,15-,21-,22-;/m0./s1
