656305-82-7 Usage
Description
3-(3,5-Dichlorophenyl)benzaldehyde, also known as 3,5-Dichlorobenzaldehyde, is a chemical compound with the molecular formula C13H8Cl2O. It is a white to pale yellow crystalline powder with a strong, aromatic odor. 3-(3,5-DICHLOROPHENYL)BENZALDEHYDE is known for its high purity and stability, making it a valuable chemical in organic synthesis and manufacturing processes.
Used in Pharmaceutical Industry:
3-(3,5-Dichlorophenyl)benzaldehyde is used as an intermediate for the production of various pharmaceuticals. It plays a crucial role in the synthesis of a wide range of medications, contributing to the development of new and improved treatments.
Used in Agrochemical Industry:
In the agrochemical industry, 3-(3,5-Dichlorophenyl)benzaldehyde is used as an intermediate in the production of various agrochemicals. Its application helps in the development of effective solutions for pest control and crop protection.
Used in Dye Industry:
3-(3,5-Dichlorophenyl)benzaldehyde is used as a raw material for the synthesis of various dyes. Its unique properties allow for the creation of a broad spectrum of colors, enhancing the dye industry's offerings.
Used in Organic Synthesis:
3-(3,5-Dichlorophenyl)benzaldehyde is used as a raw material for the synthesis of various aromatic compounds. Its versatility in organic synthesis contributes to the development of new chemical compounds with diverse applications.
It is important to handle 3-(3,5-Dichlorophenyl)benzaldehyde with care as it can be irritating to the eyes, skin, and respiratory system. Proper safety measures should be taken during its use to ensure the well-being of individuals involved in its handling and production.
Check Digit Verification of cas no
The CAS Registry Mumber 656305-82-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,6,3,0 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 656305-82:
(8*6)+(7*5)+(6*6)+(5*3)+(4*0)+(3*5)+(2*8)+(1*2)=167
167 % 10 = 7
So 656305-82-7 is a valid CAS Registry Number.
656305-82-7Relevant articles and documents
Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
Adamski-Werner, Sara L.,Palaninathan, Satheesh K.,Sacchettini, James C.,Kelly, Jeffery W.
, p. 355 - 374 (2007/10/03)
Analogues of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors of transthyretin (TTR) aggregation, including amyloid fibril formation. High inhibitory activity was observed for 26 of the compounds. Of those, eight exhibited excellent binding selectivity for TTR in human plasma (binding stoichiometry > 0.50, with a theoretical maximum of 2.0 inhibitors bound per TTR tetramer). Biophysical studies reveal that these eight inhibitors dramatically slow tetramer dissociation (the rate-determining step of amyloidogenesis) over a duration of 168 h. This appears to be achieved through ground-state stabilization, which raises the kinetic barrier for tetramer dissociation. Kinetic stabilization of WT TTR by these eight inhibitors is further substantiated by the decreasing rate of amyloid fibril formation as a function of increasing inhibitor concentration (pH 4.4). X-ray cocrystal structures of the TTR·182 and TTR·202 complexes reveal that 18 and 20 bind in opposite orientations in the TTR binding site. Moving the fluorines from the meta positions in 18 to the ortho positions in 20 reverses the binding orientation, allowing the hydrophilic aromatic ring of 20 to orient in the outer binding pocket where the carboxylate engages in favorable electrostatic interactions with the ε-ammonium groups of Lys 15 and 15′. The hydrophilic aryl ring of 18 occupies the inner binding pocket, with the carboxylate positioned to hydrogen bond to the serine 117 and 117′ residues. Diflunisal itself appears to occupy both orientations based on the electron density in the TTR·12 structure. Structure-activity relationships reveal that para-carboxylate substitution on the hydrophilic ring and dihalogen substitution on the hydrophobic ring afford the most active TTR amyloid inhibitors.
