6713-27-5 Usage
Description
Moronic acid is a naturally occurring compound with potential antidiabetic and antihyperglycemic properties. It is known for its ability to inhibit PTP-1B, a protein tyrosine phosphatase that plays a role in the regulation of blood glucose levels. Moronic acid has been shown to have sustained antidiabetic and antihyperglycemic action, possibly mediated by insulin sensitization in rat models.
Uses
Used in Pharmaceutical Industry:
Moronic acid is used as an antidiabetic agent for its ability to inhibit PTP-1B, which helps regulate blood glucose levels. This makes it a promising candidate for the development of new treatments for diabetes and related metabolic disorders.
Moronic acid is also used as an antihyperglycemic agent for its sustained action in reducing high blood sugar levels, potentially providing a long-lasting therapeutic effect for individuals with diabetes.
In addition to its direct effects on blood glucose regulation, moronic acid may also be used in the development of insulin sensitizers, which can help improve the body's response to insulin and further support the management of diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 6713-27-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,1 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6713-27:
(6*6)+(5*7)+(4*1)+(3*3)+(2*2)+(1*7)=95
95 % 10 = 5
So 6713-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C30H46O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h18-19,21-22H,8-17H2,1-7H3,(H,32,33)/t19-,21+,22-,27+,28-,29-,30+/m1/s1
6713-27-5Relevant articles and documents
An efficient synthesis of moronic and heterobetulonic acids from allobetulin
Khusnutdinova, El'Mira F.,Medvedeva, Natalya I.,Kazakov, Dmitri V.,Kukovinets, Olga S.,Lobov, Alexander N.,Suponitsky, Kirill Yu.,Kazakova, Oxana B.
, p. 148 - 151 (2016)
The reaction of acetoxyallobetulin with HClO4 in refluxing Ac2O led to a mixture of diacetoxyheterobetulin (3β,28-diacetoxy-18α,19βH-urs-20-ene), diacetoxymoradiol (3β,28-diacetoxy-olean-18(19)-ene), 3β-acetoxy-21β-acetyl-20β,28-epoxy-18α,19βH-ursane, and diacetoxy-δ-erythrodiol (3β,28-diacetoxy-olean-13(18)-ene), which were isolated by column chromatography in yields of 18%, 37%, 39%, and 2%, respectively. Deacetylation of diacetoxyheterobetulin and diacetoxymoradiol followed by Jones oxidation of the corresponding triterpene 3β,28-diols led to heterobetulonic and moronic acids with overall yields of 17% and 35% from acetoxyallobetulin, respectively. The reported route makes possible the medium-to-large scale preparation of these pharmacologically important triterpenic acids.
Efficient synthesis of morolic acid and related triterpenes starting from betulin
Zhang, Pu,Hao, Jia,Liu, Jun,Zhang, Luyong,Sun, Hongbin
experimental part, p. 4304 - 4309 (2009/10/09)
Morolic acid (1) is a naturally occurring pentacyclic triterpene whose derivatives exhibit promising anti-HIV and other biological activities. An efficient synthesis of 1 has been accomplished in 11 steps with a total yield of 24% starting from betulin. S
