6730-83-2 Usage
Description
Kaurenoic acid is a diterpene compound found in C. langsdorffii, exhibiting a range of biological activities such as anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It demonstrates cytotoxicity against various cancer cell lines and shows in vitro activity against certain bacterial strains.
Uses
Used in Pharmaceutical Industry:
Kaurenoic acid is used as an anticancer agent for its cytotoxic effects on multiple cancer cell lines, including prostate, colon, and breast cancer cells, with IC50 values ranging from 15.03 to 48.87 μg/ml.
Used in Antibacterial Applications:
Kaurenoic acid is used as an antibacterial agent, showing in vitro activity against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus with MICs ranging from 6.25 to 12.5 μg/ml.
Used in Anti-inflammatory Applications:
Kaurenoic acid is used as an anti-inflammatory agent, reducing colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.
Used in Biological Research:
Kaurenoic acid is used in biological studies for the kinetic profile of guaco syrup metabolites, such as coumarin, 7-hydroxycoumarin, o-coumaric acid, and kaurenoic acid, to identify alternative routes of coumarin metabolism in human plasma.
Check Digit Verification of cas no
The CAS Registry Mumber 6730-83-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,3 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6730-83:
(6*6)+(5*7)+(4*3)+(3*0)+(2*8)+(1*3)=102
102 % 10 = 2
So 6730-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h14-16H,1,4-12H2,2-3H3,(H,21,22)/t14-,15-,16-,18+,19+,20+/m0/s1
6730-83-2Relevant articles and documents
BIOSYNTHESIS OF GIBBERELLIN A12-ALDEHYDE, GIBBERELLIN A12 AND THEIR KAURENOID PRECURSORS FROM MEVALONIC ACID IN A CELL-FREE SYSTEM FROM IMMATURE SEED OF PHASEOLUS COCCINEUS
Turnbull, Colin G. N.,Crozier, Alan,Schwenen, Ludger,Graebe, Jan E.
, p. 97 - 102 (2007/10/02)
A cell-free system capable of gibberellin (GA) biosynthesis has been prepared from immature seed of Phaseolus coccineus.This system converted mevalonic acid (MVA) to ent-kaurene, ent-kaurenoic acid, ent-kauradienoic acid, ent-7α-hydroxykaurenoic acid, ent-6α,7α-dihydroxykaurenoic acid, GA12-aldehyde and GA12. ent-Kaurene was converted to ent-kaurenol, ent-kaurenal, ent-kaurenoic acid and ent-7α-hydroxykaurenoic acid.All identifications were by GC/MC.The pathway from MVA to GA12-aldehyde in this species thus appears to be the same as that found in cell-free preparations derived from immature seed of other species.Key Word Index-Phaseolus coccineus; Leguminosae; runner bean; seed development; biosynthesis; cell-free system; HPLC; GC/MC; gibberellin.
