70356-03-5 Usage
Description
Cefaclor monohydrate is a second-generation cephalosporin antibiotic, characterized by its broad-spectrum antibacterial properties. It is a white to off-white crystalline powder, soluble in water and slightly soluble in alcohol. Cefaclor monohydrate is known for its effectiveness against a wide range of gram-positive and some gram-negative bacteria, making it a valuable pharmaceutical agent in the treatment of various infections.
Uses
Used in Pharmaceutical Industry:
Cefaclor monohydrate is used as an antibiotic agent for the treatment of bacterial infections. Its broad-spectrum activity allows it to target a variety of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli. It is particularly effective in treating respiratory tract infections, urinary tract infections, and skin infections.
Used in Hospital Settings:
In hospitals and other healthcare facilities, Cefaclor monohydrate is used as a therapeutic agent for patients suffering from bacterial infections. Its broad-spectrum coverage and effectiveness make it a preferred choice for treating a wide range of infections, especially when the specific causative bacteria are yet to be identified.
Used in Community Medicine:
Cefaclor monohydrate is also used in community medicine to treat common bacterial infections such as bronchitis, pneumonia, and ear infections. Its availability in various dosage forms, including capsules and suspensions, makes it accessible and convenient for patients of all ages.
Contact allergens
Cefaclor is a semisynthetic cephalosporin antibiotic,
related to cefalexin, and a frequent inducer of serum
sickness-like reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 70356-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,5 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70356-03:
(7*7)+(6*0)+(5*3)+(4*5)+(3*6)+(2*0)+(1*3)=105
105 % 10 = 5
So 70356-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2
70356-03-5Relevant articles and documents
Cefaclor preparation and preparation method thereof
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Paragraph 0033; 0088; 0089, (2017/04/29)
The invention discloses a cefaclor preparation and a preparation method thereof. The preparation method comprises: preparing cefaclor crystal, pretreating a main material and auxiliary materials, weighing, mixing, forming, and packaging; wherein the preparation of the cefaclor crystal includes subjecting 7-ACCA and potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate to silylation, acylation, condensation, acid hydrolysis, extraction and cleaning, decoloring, and crystallization; the preparation comprises the cefaclor crystal as the main material and auxiliary materials, the cefaclor crystal is /=33 degrees in angle of repose, 0.50-0.60 g/m in bulk density, 0.70-0.80 g/ml in compactness and 40-60 Mum in D10 of particle size distribution, 120-140 Mum in D50 and 210-230 Mum in D90. The conversion rate of cefaclor in chemical synthesis is increased, reaction conditions are simplified, the crystal form and particle size distribution of the cefaclor crystal are improved, and the quality of finished cefaclor crystal is improved.
Process for the preparation of 3-chloro-cefem compounds
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, (2008/06/13)
The process comprises a series of stages essentially comprising the protection of the functional groups of the side chain of Ampicillin, esterification of the acid group, oxidation to sulphoxide, expansion of the thiazole ring to a thiazine ring, ozonolysis of the exomethylene cefam derivative obtained, substitution of the hydroxyl group by chlorine and de-protection of the functional groups, in which the order of some stages can be varied without affecting the final result.
