7085-55-4 Usage
Description
Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is a pharmaceutical compound with various therapeutic properties. It is known for its ability to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and enhance plasma viscosity and retinal microcirculation.
Uses
Used in Venous Disorders Treatment:
Troxerutin is used as a treatment for venous disorders, particularly chronic venous insufficiency and varicose veins. It helps to improve the symptoms and reduce the complications associated with these conditions.
Used as a Vasoprotectant:
Troxerutin serves as a vasoprotectant, which means it helps to protect blood vessels from damage and maintain their integrity. This property makes it useful in preventing and treating various vascular-related issues.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Troxerutin is used as an active ingredient in various formulations, such as tablets, capsules, and injections, for the treatment of venous disorders and as a vasoprotectant.
Used in Clinical Trials:
Troxerutin has been the subject of clinical trials to evaluate its efficacy in treating specific conditions, such as central retinal vein occlusion (CRVO). A double-blind randomized clinical trial compared troxerutin with a placebo in 27 patients with CRVO, although the study had limitations, including a small number of patients and a short follow-up time.
Originator
Venoruton,Novartis Co
Manufacturing Process
In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are
added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture
being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene
chlorohydrin being then introduced at 55°C for 10 min. When all the
chlorohydrin has been thus added the temperature is progressively raised to
75°C and maintained at this level for 2 hours. After cooling, in a nitrogen
atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric
acid. The solution is kept in an ice box for 24 hours and then filtered to
remove any impurities. At reduced pressure the solution is evaporated until
dry, the residue taken up in 3 litres of boning methanol which dissolves the
tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium
chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic
solution either by evaporation and refrigeration, or by evaporation
precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin
obtained is in the form of small very hygroscopic crystals which contain
alcohol of crystallization.These crystals are quickly shaken washed in a little
cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous
tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder
which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss
Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland
Check Digit Verification of cas no
The CAS Registry Mumber 7085-55-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,8 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7085-55:
(6*7)+(5*0)+(4*8)+(3*5)+(2*5)+(1*5)=104
104 % 10 = 4
So 7085-55-4 is a valid CAS Registry Number.
InChI:InChI=1/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33?/m0/s1
7085-55-4Relevant articles and documents
Troxerutin compound
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Paragraph 0050-0052; 0061-0065, (2020/01/14)
The invention discloses a troxerutin compound prepared by using an advanced on-line process control technology. The troxerutin compound is measured by X-ray powder diffraction, and a X-ray powder diffraction pattern expressed by a 2 diffraction angle shows characteristic diffraction peaks at the 2 of 8.15+/-0.2 degrees, 9.24+/-0.2 degrees, 12.31+/-0.2 degrees, 17.10+/-0.2 degrees, 17.92+/-0.2 degrees, 18.73+/-0.2 degrees and 23.45+/-0.2 degrees. The compound has the characteristics of high purity, low impurity content, good fluidity and good stability.
A self-priming stirred autoclave preparation of troxerutin method
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0031, (2017/06/29)
The invention discloses a method for preparing troxerutin by adopting a self-suction type stirred autoclave. The method comprises the following steps: adding raw materials namely rutin, ethylene oxide, a solvent namely methanol and a catalyst namely natural weakly-alkaline high-molecular compound chitosan into a self-suction type stirred autoclave, starting a digital control instrument, setting a temperature to be 70-90 DEG C, regulating a voltage to be 100V, setting a rotating speed to be 1000r/min, stirring and heating to reach a set temperature, and reacting for 3-6 hours; and stopping stirring after reaction is ended, rapidly cooling by using cold water, shutting down the digital control instrument, opening a reaction kettle, pouring out reaction liquid, adjusting a pH value of the poured reaction liquid to be 5-6 by using hydrochloric acid, performing suction filtration, adding a crystal seed into the reaction liquid subjected to suction filtration, standing for later crystallization, and filtering to obtain a product namely troxerutin. According to the method disclosed by the invention, the reaction raw materials are integrally added into the self-suction type stirred autoclave, so that material feeding steps can be simplified; and the adopted catalyst is natural weakly-alkaline high-molecular compound chitosan, so that the raw material is wide in source, and is natural, non-toxic and weakly-alkaline, and side reactions such as hydrolysis, oxidation and the like caused by strong alkaline catalysis can be avoided.
A high-purity of troxerutin preparation method
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Paragraph 0013; 0014, (2017/07/01)
The invention discloses a preparation method of high-purity troxerutin. According to the preparation method of the high-purity troxerutin, the synthesis and refining processes of the troxerutin are improved; sodium methoxide or sodium ethoxide is selected as a catalyst, supercritical CO2 is selected for extraction and crystallization refining of the troxerutin, and finally, the troxerutin of which the yield and the purity both are greatly improved in contrast with a traditional process can be obtained.