70978-37-9

Basic information

• Product Name: 4-Methoxybenzyl azide
• Synonyms: Benzene, 1-(azidomethyl)-4-methoxy-
• CAS NO: 70978-37-9
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.17656
• Mol File: 70978-37-9.mol
• Article Data: 159

Chemical Properties

• Melting Point: 70-71℃
• Boiling Point: 126 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.063 g/cm3 (420 ºC)
• Refractive Index: 1.5272 (589.3 nm 20℃)
• CAS DataBase Reference: 4-Methoxybenzyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxybenzyl azide(70978-37-9)
• EPA Substance Registry System: 4-Methoxybenzyl azide(70978-37-9)

Safety Data

• Hazardous Substances Data: 70978-37-9(Hazardous Substances Data)

Usage

Description

4-Methoxybenzyl azide is an organic chemical compound characterized by the molecular formula C8H9N3O. It features a methoxy group (-OCH3) attached to a benzene ring and an azide functional group (-N3), making it a versatile reagent in various chemical processes.

Uses

Used in Organic Synthesis:
4-Methoxybenzyl azide is used as a reagent for the introduction of azide groups into molecules, facilitating the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Preparation:
4-Methoxybenzyl azide is utilized as a precursor in the production of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
4-Methoxybenzyl azide is also employed in the synthesis of agrochemicals, playing a role in the creation of pesticides and other agricultural products.
Used in Click Chemistry Reactions:
4-Methoxybenzyl azide is used as a precursor in click chemistry reactions, enabling the efficient and selective production of diverse chemical compounds.
Used in Pharmaceutical and Material Science Industries:
As a building block, 4-Methoxybenzyl azide is crucial in the production of compounds used across the pharmaceutical and material science sectors, supporting the development of innovative materials and therapeutics.

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 2393-23-9 4-methoxy-benzylamine 
• 90673-97-5 methanesulfonic acid 4-methoxybenzyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 92567-07-2 1-(diazidomethyl)-4-methoxybenzene 
• 100-66-3 methoxybenzene 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 14535-12-7 (4-methoxybenzyl)-3'-cyanopyridinium chloride 
• 4648-54-8 trimethylsilylazide 
• 824-94-2 p-methoxybenzyl chloride 
• 104-93-8 p-methylanizole 
• 104-21-2 p-methoxybenzyl acetate 
• 18494-82-1 2-(4-methoxy-benzyloxy)-tetrahydro-pyran 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 141072-06-2 methyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 141071-93-4 di-tert-butyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 79707-03-2 4,9-dihydro-6,7-dimethyl-4,9-dioxo-1-(4-methoxybenzyl)naphtho<2,3-d>-v-triazole 
• 126799-88-0 dimethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 70978-35-7 ethyl 1-(4-methoxybenzyl)-1H-tetrazole-5-carboxylate 
• 133992-65-1 [1-(3,5-Dichloro-benzyl)-5-methyl-1H-[1,2,3]triazol-4-yl]-phenyl-methanone 
• 133992-64-0 1-[1-(3,5-Dichloro-benzyl)-5-phenyl-1H-[1,2,3]triazol-4-yl]-ethanone 
• 81581-05-7 ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 944480-99-3 C₁₆H₁₆N₄O₃S 
• 99451-35-1 1-p-Methoxybenzyl-5-p-Toluenesulfonyltetrazole 

Relevant articles and documents

Regioselectivity in the 1,3-dipolar cycloaddition reactions of nitrile oxides and organic azides with bromocarbazole-1,4-diones

The effect exerted by the presence of a bromine atom in 2 or 3 position of a carbazole-1,4-dione on the regiocontrol of 1,3-dipolar cycloaddition reactions with nitrile oxides and organic azides was investigated. Comparison with the results obtained with

Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents

Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is expected to increase as the global population ages. Recent studies provide increasing evidence that inflammation plays a key role in the pathogenesis and progression of AD. Diosgenin, an active ingredient in Dioscorea nipponica Makino, is a promising bioactive lead compound in the treatment of Alzheimer's disease, which exhibited anti-inflammatory activity. To search for more efficient anti-Alzheimer agents, a series of novel diosgenin-triazolyl hybrids were designed, synthesized, and their neuroprotective effects against oxygen-glucose deprivation-induced neurotoxicity and LPS-induced NO production were evaluated. Most of these new hybrids displayed better activities than DIO. In particular, the promising compound L6 not only demonstrated an excellent neuroprotective effect but also showed the best anti-inflammatory activity. The structure-activity relationship study illustrated that the introduction of benzyl or phenyl triazole did improve the activity, and the introduction of benzyl triazole was better than that of phenyl triazole. The results we obtained showed that the diosgenin skeleton could be a promising structural template for the development of new anti-Alzheimer drug candidates, and compound L6 has the potential to be an important lead compound for further research.

COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES

Disclosed herein are compounds and compositions for modulating glycolate oxidase, useful for treating oxalate-related diseases, such as hyperoxaluria, where modulating glycolate oxidase is expected to be therapeutic to a patent in need thereof. Methods of modulating glycolate oxidase activity in a human or animal subject are also provided.