76376-43-7

Basic information

• Product Name: Euphorbia factor L1
• Synonyms: EUPATOROXIN,10-EPI;10-epi-Eupatoroxin;Euphorbia Factor L1
• CAS NO: 76376-43-7
• Molecular Formula: C₃₂H₄₀O₈
• Molecular Weight: 552.66
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Diterpenoids
• Mol File: 76376-43-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 633.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Euphorbia factor L1(CAS DataBase Reference)
• NIST Chemistry Reference: Euphorbia factor L1(76376-43-7)
• EPA Substance Registry System: Euphorbia factor L1(76376-43-7)

Safety Data

• Hazardous Substances Data: 76376-43-7(Hazardous Substances Data)

Usage

General Description

Euphorbia factor L1 is a toxic chemical found in the Euphorbia plant genus that is known for its ability to cause skin irritation and blistering upon contact. It is classified as a diterpene ester, and it is a potent irritant to the skin and mucous membranes. Euphorbia factor L1 is also responsible for the plant's potential as a source of natural rubber and has been investigated for its potential use in cancer therapy due to its cytotoxic effects. However, due to its toxicity, it requires careful handling and management to prevent exposure and adverse effects in humans and animals.

Upstream product

• 247099-01-0 lathyrol-3-phenylacetate-5,15-diacetate 

Relevant articles and documents

Epoxidation studies on lathyra-6(17),12-dienes - Revised structure of the Euphorbia Factor L1

As part of an investigation aimed at mimicking certain steps of the biogenesis of the polycyclic Euphorbia diterpenoids from macrocyclic precursors, the epoxidation of lathyrol and its esters with (peroxy/peroxo)metal complexes and non-metal (peracids and dioxiranes) oxidants was investigated. Treatment of lathyrol esters with methyl(trifluoromethyl)-dioxirane gave 6(17)β-epoxides as the only reaction products in very high yield. Conversely, lathyrol itself proved amenable to epoxidation only with the TBHP-VO(acac)2 protocol. Surprisingly, the reaction was not chemoselective, and also the enone double bond was epoxidized, eventually affording a rearranged compound of the 14(13→12)-abeo-lathyrane type. Based on the stereochemical course of the epoxidation of lathyrol esters and on NMR experiments on the natural product, the configuration at C-6 of the Euphorbia Factor L1 was revised, overturning a thirty-year misconception on the structure of this compound.