76899-07-5

Basic information

• Product Name: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]- 2-azetidinone
• Synonyms: (3R)-3α-[(R)-1-(tert-Butyldimethylsilyloxy)ethyl]-4β-acetoxyazetidine-2-one;(3R)-4β-Acetoxy-3α-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidine-2-one;(3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsiloxy)ethyl]-2-Azetidinone;Acetic acid (2R)-3β-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-oxoazetidin-2α-yl ester;Acetic acid [(3R)-3α-[(R)-1-[(tert-butyldimethylsilyl)oxy]ethyl]-2-oxoazetidine]-4β-yl ester
• CAS NO: 76899-07-5
• Molecular Weight: 287.431
• Mol File: 76899-07-5.mol
• Article Data: 55

Chemical Properties

• CAS DataBase Reference: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]- 2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]- 2-azetidinone(76899-07-5)
• EPA Substance Registry System: (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]- 2-azetidinone(76899-07-5)

Safety Data

• Hazardous Substances Data: 76899-07-5(Hazardous Substances Data)

Upstream product

• 79-21-0 peracetic acid 
• 109323-90-2 (1'R,3S)-3-<1'-<(tert-butyldimethylsilyl)oxy>ethyl>azetidin-2-one 
• 2754-27-0 trimethylsilyl acetate 
• 144069-72-7 (3S,4R)-3-<(1R)-1-(tert-Butyldimethylsiloxy)ethyl>-4-phenylsulfinylazetidin-2-one 
• 64-19-7 acetic acid 
• 123-62-6 propionic acid anhydride 
• 127-09-3 sodium acetate 
• 111408-23-2 (3S,4S)-4-Ethynyl-3-<(1R)-hydroxyethyl>-2-azetidinone 
• 1180012-46-7 (3S,4R)-benzyl N-(p-toluenesulfonyl)-3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate 
• 1180012-50-3 (3S,4R)-benzyl 3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate 
• 105729-41-7 3-(R)-t-butyldimethylsilyloxybutanoic acid 
• 115936-64-6 (3S,4R)-3-<(R)-1'-(dimethyl-t-butylsilyloxy)ethyl>-4-oxoazetidin-2-carboxylic acid 
• 107265-57-6 (R)-3-(tert-butyldimethylsiloxy)butanoyl chloride 
• 85253-97-0 (2S,3S)-3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidine-2-carboxylic acid 

Downstream Products

• 88035-31-8 (3S,4R)-3-((R)-1-(t-butyldimethylsilyloxy)ethyl)-4-triphenylmethylthio-2-azetidinone 
• 87392-18-5 <3S-<3α(S^*),4β>>-benzyl<3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate 
• 135297-22-2 (3S,4R)-3-<(R)-1-tert-butyldimethylsilyloxy-ethyl>-4-<(2'S,6'S)-6'-methoxy-1-oxo-cyclohex-2'-yl>-azetidin-2-one 
• 175891-54-0 (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((1S,3S)-3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one 
• 135413-17-1 (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((1R,3R)-3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one 
• 220430-44-4 (S)-6-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-cyclohex-1-enecarboxylic acid ethyl ester 
• 592528-33-1 (3S)-3-[(1R)-1-(tert-butyldimethylsilanyloxy)ethyl]-4-[(1Z)-2-oxo-2-phenylethylidene]azetidin-2-one 
• 786709-79-3 (3S,4R)-3-[(R)-tert-butyldimethylsilyloxyethyl]-4-[(phenylmethyl)seleno]-2-azetidinone 
• 786709-80-6 tert-butyl 3-[(3S,4R)-(R)-tert-butyldimethylsilyloxyethyl]-2-oxo-4-[(phenylmethyl)seleno]-1-azetidineacetate 
• 786709-89-5 (3S,4R)-3-[(R)-tert-butyldimethylsilyloxyethyl]-1-[(2-iodophenyl)methyl]-4-[(phenylmethyl)seleno]-2-azetidinone 
• 786709-82-8 3-carbo-(tert-butoxy)-3-[(3S,4R)-3-[(R)-tert-butyldimethylsilyloxyethyl]-2-oxo-4-[(phenylmethyl)seleno]-1-azetidinyl]propanoic acid 
• 786709-84-0 1-tert-butyl 4-ethyl [(3S,4R)-3-[(R)-tert-butyldimethylsilyloxyethyl]-2-oxo-4-[(phenylmethyl)seleno]-1-azetidinyl]butanedioate 
• 847927-80-4 C₂₉H₄₆N₂O₆S₂SeSi 
• 608535-33-7 {3-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-ylidene}-thioacetic acid S-phenyl ester 

Relevant articles and documents

Preparation method of azetidinone compound and preparation method 4 - acyloxy-azetidinone compound

The invention provides a preparation method of a azetidinone compound and a preparation method of 4 - acyloxy-azetidinone compound. The preparation method comprises the following steps S1, an epoxy amide compound reacts with I alkali reagents to form a ring reaction, and first 1st reaction systems are obtained. Step S2: The first reaction system is subjected to hydroxyl protection reaction with a raw material including a silanization reagent and a nitrogen-containing basic organic matter to obtain second reaction systems. In step S3, second reaction system and second base reagent are subjected to isomerization reaction to obtain the azetidinone compound, wherein the epoxy amide compound has the structure shown VI, the separation process of the isomer product of the structure shown II and formula III IV is avoided, and the selectivity and yield of the azetidinone compound are improved.

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