7766-23-6Relevant articles and documents
Discovery of novel small-molecule inhibitors of pd-1/pd-l1 interaction via structural simplification strategy
Du, Huijie,Huang, Shihui,Li, Hui,Liu, Jinchang,Xia, Yu,Xu, Yungen,Yu, Chunqiu,Zhang, Hongbo,Zhu, Qihua,Zou, Yi
, p. 3347 - 3347 (2021)
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer tr
Novel biphenyl derivative as well as preparation method and medical application thereof
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Paragraph 0037; 0065-0069, (2021/07/21)
The invention relates to the field of medicinal chemistry, and discloses biphenyl derivatives with PD-1/PD-L1 inhibitory activity as well as a preparation method and application of the biphenyl derivatives. The invention further discloses a composition containing the biphenyl derivative with the PD-1/PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and application of the biphenyl derivative in preparation of a PD-1/PD-L1 inhibitor. The compound can be used for treating tumors.
Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd0-Catalyzed Asymmetric C(sp3)-H Activation
Melot, Romain,Craveiro, Marcus V.,Bürgi, Thomas,Baudoin, Olivier
supporting information, p. 812 - 815 (2019/01/21)
A divergent enantioselective synthesis of (nor)illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C(sp3)-H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the targe