79-83-4 Usage
Description
D-Pantothenic acid, also known as Vitamin B5, is a vital component of the B complex vitamins that plays a crucial role in the biosynthesis of coenzyme A in mammalian cells. It is ubiquitously found in all animal and plant tissues, with liver being a common source, while the jelly of the queen bee contains six times as much as liver. Rice bran and molasses are also good sources of this essential vitamin.
Uses
Used in Pharmaceutical Industry:
D-Pantothenic acid is used as a pharmaceutical ingredient for its essential role in the biosynthesis of coenzyme A, which is vital for various cellular processes.
Used in Nutritional Supplements:
As a member of the B complex vitamins, D-Pantothenic acid is used as a nutritional supplement to support proper growth and maintenance of the body. It is involved in energy release from carbohydrates and metabolism of fatty acids.
Used in Food and Beverage Industry:
D-Pantothenic acid is used as a food additive to fortify products with this essential vitamin, ensuring adequate intake for proper body functions.
Used in Cosmetics Industry:
D-Pantothenic acid is used in cosmetics for its potential benefits to skin health, such as promoting skin regeneration and maintaining skin moisture.
Used in Animal Feed Industry:
D-Pantothenic acid is used as a supplement in animal feed to ensure the proper growth and health of livestock.
Labelled Pantothenic Acid:
Labelled D-Pantothenic acid is used in research and diagnostic applications, allowing for the tracking and study of metabolic pathways and enzyme activities in various biological systems.
Vitamin B5:
Being water-soluble, D-Pantothenic acid (Vitamin B5) is essential for maintaining the stability of the vitamin through storage and is found in various food sources such as liver, eggs, and meat.
Originator
Panto-250 , Bio-Tech Pharmacal
Manufacturing Process
Isobutylaldehyde reacted with formaldehyde in the presence potassium chromate as a result 2,2-dimethyl-3-hydroxy-propanal was obtained.The 2,2-dimethyl-3-hydroxy-propanal was treated by sodium cyanide so 2,4dihydroxy-3,3-dimethyl-butironitrile was prepared.
The 2,4-dihydroxy-3,3-dimethyl-butironitrile was treated hydrochloric acid and D,L-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one (D,L-pantolacton) was obtained. The racemic mixture of D- and L-pantolactons was a division of Dand L- isomers by the adding of α-phenylethylamine. So D-pantolacton was isolated.
Acrylic acid contacted with NH3and β-alanine was obtained.
D-Pantalacton reacted with β-alanine as a result 3-(2,4-dihydroxy-3,3dimethyl-butyrylamino)-propanoic acid was produced
Safety Profile
Moderately toxic by subcutaneous and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 79-83-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 79-83:
(4*7)+(3*9)+(2*8)+(1*3)=74
74 % 10 = 4
So 79-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)/t7-/m0/s1
79-83-4Relevant articles and documents
McBurney,Bollen,Williams
, p. 301 (1935)
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Mueller,Klotz
, p. 3086 (1938)
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Weinstock et al.
, p. 1421,1424 (1939)
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Chemical Proteomic Profiling of Protein 4′-Phosphopantetheinylation in Mammalian Cells
Chen, Nan,Li, Yuanpei,Liu, Yuan,Wang, Chu
supporting information, p. 16069 - 16075 (2020/07/21)
Protein 4′-phosphopantetheinylation is an essential post-translational modification (PTM) in prokaryotes and eukaryotes. So far, only five protein substrates of this specific PTM have been discovered in mammalian cells. These proteins are known to perform important functions, including fatty acid biosynthesis and folate metabolism, as well as β-alanine activation. To explore existing and new substrates of 4′-phosphopantetheinylation in mammalian proteomes, we designed and synthesized a series of new pantetheine analogue probes, enabling effective metabolic labelling of 4′-phosphopantetheinylated proteins in HepG2 cells. In combination with a quantitative chemical proteomic platform, we enriched and identified all the currently known 4′-phosphopantetheinylated proteins with high confidence, and unambiguously determined their exact sites of modification. More encouragingly, we discovered, using targeted chemical proteomics, a potential 4′-phosphopantetheinylation site in the protein of mitochondrial dehydrogenase/reductase SDR family member 2 (DHRS2).
PANTETHEINE DERIVATIVES AND USES THEREOF
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Paragraph 2065, (2020/06/19)
The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
Probing the ligand preferences of the three types of bacterial pantothenate kinase
Guan, Jinming,Barnard, Leanne,Cresson, Jeanne,Hoegl, Annabelle,Chang, Justin H.,Strauss, Erick,Auclair, Karine
supporting information, p. 5896 - 5902 (2018/11/23)
Pantothenate kinase (PanK) catalyzes the transformation of pantothenate to 4′-phosphopantothenate, the first committed step in coenzyme A biosynthesis. While numerous pantothenate antimetabolites and PanK inhibitors have been reported for bacterial type I and type II PanKs, only a few weak inhibitors are known for bacterial type III PanK enzymes. Here, a series of pantothenate analogues were synthesized using convenient synthetic methodology. The compounds were exploited as small organic probes to compare the ligand preferences of the three different types of bacterial PanK. Overall, several new inhibitors and substrates were identified for each type of PanK.
