81110-73-8Relevant articles and documents
Enantioseparation of racecadotril using polysaccharide-type chiral stationary phases in polar organic mode
Szabó, Zoltán-István,Foroughbakhshfasaei, Mohammadhassan,Noszál, Béla,Tóth, Gerg?
, p. 95 - 105 (2018)
Enantioseparation of the antidiarrheal drug, racecadotril, was investigated by liquid chromatography using polysaccharide-type chiral stationary phases in polar organic mode. The enantiodiscrimininating properties of 4 different chiral columns (Chiralpak
A by 3 - phenyl -1 - methylacetylene preparation quickly disintegrating process method (by machine translation)
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, (2019/07/10)
A by 3 - phenyl - 1 - propyne preparation quickly disintegrating process method, which belongs to the technical field of pharmaceutical intermediates. In the preparation quickly disintegrating in the process, intermediate benzyl acrylic acid yield and purity of the most important, this method first using 3 - phenyl - 1 - propyne as the raw material, in the palladium catalyst Pd2 (Dba)3 And the ligand dppp with ethyl carbonate under the catalysis of the reaction to the one-step synthesis of benzyl acrylic acid, its advantage lies in atmospheric pressure to complete the addition reaction, functional group tolerance is good, high efficiency, high purity, the production process is greatly simplified, and to obtain the target product preparation process of yield and purity than the traditional process much higher. The method has the advantages of greatly improve the productivity, reduce the cost, improve the safety, energy saving and the like, in accordance with the green reaction of modern chemical production requirement. (by machine translation)
Preparation method and detection method for ecadotril
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, (2018/03/26)
The invention provides a preparation method and detection method for ecadotril. 2-benzyl-3-hydroxypropionic acid is used as a raw material, and a four-step method is employed for preparing an intermediate and ecadotril, so more options are provided for acquisition of the bulk drug ecadotril. At the same time, based on the fact that (R)-phenylethylamine has slightly different abilities in elution of ecadotril and ecadotril enantiomers, a liquid-phase detection method for racecadotril in European Pharmacopoeia is employed for separation and detection in a liquid-phase system of an achiral column. The detection method is simple to operate and easy to implement.