81203-50-1 Usage
Description
(3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one is a complex organic compound with a unique molecular structure. It is a derivative of oxolan-2-one, featuring a series of chiral centers and functional groups that contribute to its distinct properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one is used as a pharmaceutical intermediate for the development of novel drugs targeting various diseases. Its unique structure and chiral centers allow for the design of enantiomerically pure compounds with potential therapeutic benefits.
Used in Chemical Research:
In the field of chemical research, this compound serves as a valuable subject for studying the synthesis, reactivity, and properties of complex organic molecules. Its unique structure provides opportunities for exploring new reaction pathways and developing innovative synthetic methods.
Used in Material Science:
(3R,5S)-5-[(2R)-2-[(1R,3aR,4E,7aR)-4-[(2Z)-2-[(3S,5S)-3,5-dihydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-hydroxy-3-methyl-oxolan-2-one can be utilized in the development of new materials with specific properties, such as chiral catalysts, sensors, or functional polymers. Its unique molecular architecture offers potential for creating materials with tailored characteristics for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 81203-50-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,0 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 81203-50:
(7*8)+(6*1)+(5*2)+(4*0)+(3*3)+(2*5)+(1*0)=91
91 % 10 = 1
So 81203-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C27H40O5/c1-16(12-21-15-27(4,31)25(30)32-21)22-9-10-23-18(6-5-11-26(22,23)3)7-8-19-13-20(28)14-24(29)17(19)2/h7-8,16,20-24,28-29,31H,2,5-6,9-15H2,1,3-4H3/b18-7+,19-8-/t16-,20-,21+,22-,23+,24+,26-,27-/m1/s1
81203-50-1Relevant articles and documents
Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25
Nagata, Akiko,Akagi, Yusuke,Masoud, Shadi Sedghi,Yamanaka, Masahiro,Kittaka, Atsushi,Uesugi, Motonari,Odagi, Minami,Nagasawa, Kazuo
, p. 7630 - 7641 (2019/05/16)
(23S,25R)-Calcitriol lactone is a major metabolite of vitamin D3, but its synthesis has been far less well investigated than that of 1α,25(OH)2 vitamin D3, the active form of vitamin D3, even though the lactone
Facile Stereoselective Synthesis of (23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-Lactone, a Major Metabolite of 1α,25-Dihydroxyvitamin D3
Yamamoto, Keiko,Shimizu, Masato,Yamada, Sachiko,Iwata, Suguru,Hoshino, Osamu
, p. 33 - 39 (2007/10/02)
(23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-lactone (1a), a major metabolite of 1α,25-dihydroxyvitamin D3 2, was synthesized efficiently and stereoselectively from 1α-hydroxydehydroepiandrosterone (3).The 17-oxosteroid 3 was first converted to C(22)-steroid aldehyde 9 with the natural stereochemistry at C(17) and C(20) using a stereoselective ene reaction as the key step.Then it was combined with the chiral C5 sulfone 4 having the correct stereochemistry for the lactone in 1a.Sulfone 4 was readily obtained from commercially available (R)-citramalic acid.The side-chain lactone with the natural stereochemistry at C(23) was constructed with high stereoselectivity (84percent) by iodo lactonization of the Δ22-26-carboxylic acid 16b under kinetically controlled conditions in the presence of γ-collidine.The stereoselectivity of the iodo lactonization of steroidal Δ22-25-hydroxy-26-carboxylic acids 16b, 24, and 25 was studied in detail, and a mechanism is proposed in which the configuration at C(25) and an added pyridine base play an important role.