82209-76-5 Usage
Description
Andrographoside is a natural terpenoid compound derived from the plant Andrographis paniculata, commonly known as the "King of Bitters." It possesses a unique structure that contributes to its diverse range of biological activities, including anti-inflammatory, immunomodulatory, and cell signaling effects. Its ability to modulate various cellular pathways and processes makes it a promising candidate for therapeutic applications.
Uses
Used in Pharmaceutical Industry:
Andrographoside is used as a therapeutic agent for its anti-inflammatory properties, making it a potential treatment for various inflammatory conditions. Its immunomodulatory effects also contribute to its potential use in managing immune system-related disorders.
Used in Nutraceutical Industry:
Andrographoside is used as a dietary supplement for its health-promoting benefits, such as enhancing the immune system and providing support for overall well-being. Its natural origin and wide range of effects make it an attractive option for consumers seeking natural alternatives to synthetic medications.
Used in Cosmetic Industry:
Andrographoside is used as an active ingredient in skincare products for its anti-inflammatory and cell signaling properties. It may help reduce inflammation, promote skin healing, and improve overall skin health, making it a valuable addition to cosmetic formulations.
Used in Research Applications:
Andrographoside is used as a research tool for studying the mechanisms of action behind its various biological activities. Its role in modulating cell signaling pathways and immune responses can provide valuable insights into the development of new therapeutic strategies and drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 82209-76-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,2,0 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82209-76:
(7*8)+(6*2)+(5*2)+(4*0)+(3*9)+(2*7)+(1*6)=125
125 % 10 = 5
So 82209-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H40O10/c1-13-4-7-18-25(2,15(13)6-5-14-16(28)11-34-23(14)33)9-8-19(29)26(18,3)12-35-24-22(32)21(31)20(30)17(10-27)36-24/h5,15-22,24,27-32H,1,4,6-12H2,2-3H3/b14-5+/t15?,16-,17-,18+,19-,20-,21+,22-,24-,25+,26+/m1/s1
82209-76-5Relevant articles and documents
Efficient enzymatic synthesis and antibacterial activity of andrographolide glycoside
Qiao, Ying,Huang, Yao,Feng, Fang,Chen, Zhi-Gang
, p. 675 - 680 (2016)
19-O-β-Galactosyl andrographolide, a potential novel antibacterial agent, was synthesized through enzymatic transgalactosylation of andrographolide in co-solvent systems. Organic solvents and their contents have important influences on the regioselective galactosylation of andrographolide catalyzed by β-galactosidase from bovine liver in co-solvent systems. β-Galactosidase showed high activity and stability in 5-15% (v/v) DMSO with 22-52% total molar yields of andrographolide glycosides. The addition of hydrophilic DMSO not only greatly promoted the solubility of the substrate, but also improved the reaction efficiency of the process. β-Galactosidase displayed absolute regioselectivity toward the 19-position of andrographolide. The solubility of andrographolide glycoside in water was 42.1 mg ml-1, which is about 702 times that of andrographolide. The glycosylated andrographolide showed antibacterial activity against five representative species of food-borne pathogenic bacteria [with minimal inhibitory concentrations (MICs) as low as 8 μg ml-1], whereas andrographolide exhibited no such activity. These results indicate an enzymatic modification was not only facile and green, but an effective method for the preparation of an andrographolide monoglycoside.
