830-50-2Relevant articles and documents
Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
Sun, Xiang,Ritter, Tobias
supporting information, p. 10557 - 10562 (2021/04/05)
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with bro
Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands
Brüning, Fabian,Nagae, Haruki,K?ch, Daniel,Mashima, Kazushi,Togni, Antonio
supporting information, p. 10818 - 10822 (2019/07/31)
The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.
Synthetic method for optical pure penta-fluo-phenethyl alcohol
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Paragraph 0013, (2017/08/31)
The invention relates to resolution of a phenethyl alcohol compound and especially relates to a synthetic method for optical pure penta-fluo-phenethyl alcohol, mainly aiming at solving the technical problems of long synthetic route of a penta-fluo-phenethyl alcohol asymmetric synthesis method and industrial use limitation of an enzymolysis resolution method. According to the technical scheme provided by the invention, the synthetic method for optical pure penta-fluo-phenethyl alcohol comprises the following steps: reducing pentafluoroacetophenone with sodium borohydride, reacting with phthalic anhydride to generate a benzoic acid derivative, and then chemically resolving the benzoic acid derivative with chiral phenylethylamine, removing phenylethylamine with diluted hydrochloric acid, resolving the phthalic acid group with alkali, extracting, drying, filtering and concentrating, thereby acquiring the optical pure penta-fluo-phenethyl alcohol product.