83237-27-8

Basic information

• Product Name: 1-(2-Hydroxyethyl)cyclobutanol
• Synonyms: 1-(2-Hydroxyethyl)cyclobutanol
• CAS NO: 83237-27-8
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.15828
• Mol File: 83237-27-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 102 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.049 g/cm3
• PKA: 14.90±0.20(Predicted)
• CAS DataBase Reference: 1-(2-Hydroxyethyl)cyclobutanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Hydroxyethyl)cyclobutanol(83237-27-8)
• EPA Substance Registry System: 1-(2-Hydroxyethyl)cyclobutanol(83237-27-8)

Safety Data

• Hazardous Substances Data: 83237-27-8(Hazardous Substances Data)

Usage

General Description

1-(2-Hydroxyethyl)cyclobutanol is a chemical compound with the molecular formula C7H14O2. It is a cyclobutan-1-ol derivative with a hydroxyethyl substituent at the 2-position. 1-(2-Hydroxyethyl)cyclobutanol is a colorless liquid with a pleasant odor and is soluble in water and most organic solvents. It is primarily used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and properties make it a valuable intermediate in organic synthesis and a versatile building block for the creation of new chemical entities. Additionally, it is used in the production of fragrances and flavors due to its pleasant odor.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1191-95-3 cyclobutanone 
• 73039-83-5 1-oxa-spiro[2.3]hexane-2-carboxylic acid ethyl ester 
• 67-56-1 methanol 
• 73637-29-3 5,7-dioxaspiro<3.5>nonane 

Downstream Products

• 955930-07-1 2-(1-hydroxycyclobutyl)ethyl 4-methylbenzenesulfonate 
• 1369331-33-8 C₂₀H₂₃ClO₂S 
• 1369331-42-9 4-oxa-5-phenylspiro[3.4]octane 

Relevant articles and documents

A new approach to the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans by the 1,5-CH insertion reaction of magnesium carbenoids

1-Alkoxy-1-[2-chloro-2-(p-tolylsulfinyl)ethyl]cycloalkanes were prepared from various cyclic ketones in good overall yields. Treatment of these cycloalkanes bearing a sulfinyl group with i-PrMgCl resulted in the formation of 1-oxaspiro[4.n]alkanes in high to quantitative yields via the 1,5-CH insertion reaction of generated magnesium carbenoid intermediates. When this procedure was commenced with acyclic ketones, multi-substituted tetrahydrofurans were obtained in up to a 96% yield. This procedure provides a new and good way for the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans with the formation of a carbon-carbon bond between a carbenoid carbon and a non-activated carbon in high yields. The oxygen atom in the magnesium carbenoid intermediates was proved to act very important roles in the 1,5-CH insertion reaction.

PREPARATION OF 1-VINYLCYCLOBUTENE FROM METHYLENECYCLOBUTANE BY THE PRINS REACTION

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