84880-03-5 Usage
Description
Cefpimizole is a third-generation cephalosporin antibiotic, characterized by a somewhat narrower spectrum of activity compared to cefotaxime and cefoperazone. It is a semi-synthetic β-lactam antibiotic that is effective against a range of bacteria, including both Gram-negative and Gram-positive organisms.
Used in Pharmaceutical Industry:
Cefpimizole is used as an antibacterial agent for the treatment of various bacterial infections. Its narrow spectrum of activity allows for targeted treatment of specific bacterial strains, reducing the risk of collateral damage to beneficial bacteria and minimizing the potential for antibiotic resistance development.
Antimicrobial activity
A semisynthetic parenteral cephalosporin. It exhibits modest
activity compared to other antipseudomonal cephalosporins.
Like cefoperazone, it is susceptible to many enterobacterial
β-lactamases. In volunteers receiving 0.1–1 g intramuscularly,
mean peak plasma concentrations reached 15–20 and
35–40 mg/L, respectively. There was no accumulation when
the dose was repeated every 8 h for 7 days. No metabolites
have been detected. The plasma elimination half-life is 1.8–
2.1 h. The principal route of elimination is renal, 70–80%
being recovered unchanged in the urine.
Significant pain at the site of infection has been a prominent
adverse event. It is no longer widely available.
Check Digit Verification of cas no
The CAS Registry Mumber 84880-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,8,8 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 84880-03:
(7*8)+(6*4)+(5*8)+(4*8)+(3*0)+(2*0)+(1*3)=155
155 % 10 = 5
So 84880-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C28H26N6O10S2/c35-23(18(16-4-2-1-3-5-16)31-24(36)19-20(27(38)39)30-14-29-19)32-21-25(37)34-22(28(40)41)17(13-45-26(21)34)12-33-9-6-15(7-10-33)8-11-46(42,43)44/h1-7,9-10,14,18,21,26H,8,11-13H2,(H5-,29,30,31,32,35,36,38,39,40,41,42,43,44)/t18-,21-,26-/m1/s1