87150-14-9

Basic information

• Product Name: 5-[4-(Trifluoromethyl)phenyl]-1,3-oxazole
• Synonyms: 5-[4-(Trifluoromethyl)phenyl]-1,3-oxazole;5-(4-(Trifluoromethyl)phenyl)oxazole
• CAS NO: 87150-14-9
• Molecular Formula: C₁₀H₆F₃NO
• Molecular Weight: 213.1559496
• Mol File: 87150-14-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-[4-(Trifluoromethyl)phenyl]-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(Trifluoromethyl)phenyl]-1,3-oxazole(87150-14-9)
• EPA Substance Registry System: 5-[4-(Trifluoromethyl)phenyl]-1,3-oxazole(87150-14-9)

Safety Data

• Hazardous Substances Data: 87150-14-9(Hazardous Substances Data)

Upstream product

• 288-42-6 oxazol 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 778581-67-2 2-phenyl-5-[4-(trifluoromethyl)phenyl]-1,3-oxazole 
• 1146696-18-5 4-bromo-5-[4-(trifluoromethyl)phenyl]oxazole 
• 1238893-96-3 2-chloro-5-(4-(trifluoromethyl)phenyl)oxazole 
• 1238894-01-3 2,4-dibromo-5-[4-(trifluoromethyl)phenyl]oxazole 
• 1221576-94-8 5-(4-trifluoromethylphenyl)-2-[(triisopropylsilyl)ethynyl]oxazole 
• 1240321-74-7 (E)-5-(4-trifluoromethylphenyl)-2-(4-octen-4-yl)oxazole 
• 1258619-25-8 2-n-hexyl-5-[4-(trifluoromethyl)phenyl]oxazole 
• 1258619-26-9 2-[4-(2-methyl-1,3-dioxolan-2-yl)butyl]-5-[4-(trifluoromethyl)phenyl]oxazole 
• 1415114-14-5 3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenol 
• 1552274-01-7 1-cyclopentyl-5-(4-trifluoromethylphenyl)-1H-imidazole 
• 1552274-08-4 1-[2-(4-fluorophenyl)ethyl]-5-(4-trifluoromethylphenyl)-1H-imidazole 
• 1552274-22-2 1-cyclopropylmethyl-5-(4-trifluoromethylphenyl)-1H-imidazole 

Relevant articles and documents

Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts

Two sets of reaction conditions for the regiodivergent C2- or C5- direct arylations of oxazole are reported. In both cases, phosphine-free catalysts and inexpensive bases were employed allowing the access to the arylated oxazoles in moderate to high yields. Using Pd(OAc)2/KOAc as catalyst and base, regioselective C5-arylations were observed; whereas, using Pd(acac)2/Cs2CO3 system, the arylation occurred at the C2-position of oxazole. The higher reactivity of C5-H bond of oxazole as compared to the C2-H bond in the presence of Pd(OAc)2/KOAc system is consistent with a concerted metalation deprotonation mechanism; whereas the C2-arylation likely occurs via a simple base deprotonation of the oxazole C2-position. Then, from these C2- or C5-arylated oxazoles, a second palladium-catalyzed direct C?H bond arylation affords 2,5-diaryloxazoles with two different aryl groups. We also applied these sequential arylations to the straightforward synthesis of 2-arylphenanthro[9,10-d]oxazoles via three C?H bond functionalization steps. The Ru-catalyzed C?H arylation of the aryl unit of 2-aryloxazoles is also described. (Figure presented.).

Nickel-catalyzed decarboxylative arylation of heteroarenes through sp2 C-H functionalization

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aroma

Copper-mediated dehydrogenative biaryl coupling of naphthylamines and 1,3-azoles

A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds s