9010-34-8 Usage
Description
Thyroglobulin, Human is a large glycoprotein with a molecular weight of 660,000 Da that plays a crucial role in the synthesis and storage of thyroid hormones T4 and T3. It accounts for about one-third of the weight of the thyroid gland and carries various tyrosyl residues, including monoiodo-L-tyrosine, diiodo-L-tyrosine, T3, and T4. The synthesis of thyroid hormones is regulated by thyrotropin (TSH) and depends on an exogenous supply of iodide. Thyroglobulin is essential for the formation of thyroid hormones, which involves a complex sequence of events, including the active uptake of iodide, oxidation, formation of iodotyrosyl residues, proteolysis, and release of T4 and T3 into the blood.
Uses
Used in Pharmaceutical Industry:
Thyroglobulin, Human is used as an active pharmaceutical ingredient in the drug Proloid by Parke-Davis. It plays a vital role in the treatment of various thyroid-related conditions.
Used in Research and Diagnostic Applications:
Thyroglobulin, Human is often used as a carrier protein for the production of antibodies. Its advantage lies in the large number of tyrosine residues that can be used for conjugation using the diazo reaction, making it a valuable tool in research and diagnostic applications related to thyroid function and related disorders.
Biological Functions
Thyroid hormones regulate the turnover of carbohydrates, lipids, and proteins. They promote glucose
absorption, hepatic and renal gluconeogenesis, hepatic glycogenolysis, and glucose utilization in muscle
and adipose tissue. They increase de novo cholesterol synthesis but increase low-density lipoprotein
degradation and cholesterol disposal even more, leading to a net decrease in total and in low-density
lipoprotein cholesterol plasma levels. Thyroid hormones are anabolic when present at normal
concentrations; they then stimulate the expression of many key enzymes of metabolism.
Biochem/physiol Actions
Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.
Mechanism of action
The two most important actions of thyroid hormone are those related to oxygen consumption and those
related to protein synthesis. Most effects of thyroid hormones can be related to the activation of genes
following the binding of the hormone to high-affinity receptors of cell nuclei, but direct interactions of
thyroid hormones with other cellular receptors cannot be excluded.
Check Digit Verification of cas no
The CAS Registry Mumber 9010-34-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,1 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 9010-34:
(6*9)+(5*0)+(4*1)+(3*0)+(2*3)+(1*4)=68
68 % 10 = 8
So 9010-34-8 is a valid CAS Registry Number.
