937606-68-3 Usage
Description
1-(2-chloroacetyl)indolin-2-one is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a chloroacetyl group attached to an indolin-2-one core.
Uses
Used in Pharmaceutical Industry:
1-(2-chloroacetyl)indolin-2-one is used as an intermediate in the synthesis of N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide (D452513), a potent inhibitor of MELK. 1-(2-chloroacetyl)indolin-2-one has been studied for its ability to inhibit the expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth, making it a potential candidate for cancer treatment.
Additionally, 1-(2-chloroacetyl)indolin-2-one is used in the synthesis of Intedanib (I666650), an antitumor agent. It is also involved in the production of N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide, which is an impurity of Intedanib. The development of this compound as an intermediate contributes to the advancement of cancer research and the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 937606-68-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,7,6,0 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 937606-68:
(8*9)+(7*3)+(6*7)+(5*6)+(4*0)+(3*6)+(2*6)+(1*8)=203
203 % 10 = 3
So 937606-68-3 is a valid CAS Registry Number.