98555-00-1 Usage
Description
7-Amino-2(1H)-quinoxalinone, also known as 7-AQ, is a heterocyclic chemical compound characterized by a quinoxalinone core structure. It is a yellow crystalline solid that is utilized in a variety of chemical and pharmaceutical applications. 7-AQ serves as a versatile building block for the synthesis of various organic compounds and functions as an intermediate in the production of pharmaceuticals, dyes, and agrochemicals. Its potential anticancer and antiviral properties have been studied, with demonstrated inhibitory activity against several enzymes and receptors. 7-Amino-2(1H)-quinoxalinone is recognized as a valuable compound in the field of organic chemistry, with promising applications in the development of new drugs and materials.
Uses
Used in Pharmaceutical Industry:
7-Amino-2(1H)-quinoxalinone is used as a key intermediate in the synthesis of pharmaceuticals for its potential anticancer and antiviral properties. It plays a crucial role in the development of new drugs targeting various diseases and conditions.
Used in Dye Industry:
7-AQ is used as an intermediate in the production of dyes, contributing to the creation of a range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Agrochemical Industry:
In the agrochemical sector, 7-Amino-2(1H)-quinoxalinone is utilized as an intermediate for the synthesis of agrochemicals, which are essential for the development of pesticides and other products to protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
7-AQ serves as a valuable compound in the field of organic chemistry, where it is used in research to explore new synthetic pathways, develop novel compounds, and enhance our understanding of chemical reactions and mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 98555-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,5,5 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98555-00:
(7*9)+(6*8)+(5*5)+(4*5)+(3*5)+(2*0)+(1*0)=171
171 % 10 = 1
So 98555-00-1 is a valid CAS Registry Number.
98555-00-1Relevant articles and documents
Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics
Zhu, Haizhou,Mishra, Rosalin,Yuan, Long,Abdul Salam, Safnas F.,Liu, Jing,Gray, George,Sterling, Alyssa D.,Wunderlich, Mark,Landero-Figueroa, Julio,Garrett, Joan T.,Merino, Edward J.
supporting information, p. 1933 - 1939 (2019/11/19)
In this work, we designed a prodrug that reacts with cellular oxidative equivalents leading to ether cleavage and cyclization to release an active phosphatidylinositol 3-kinase (PI3K) inhibitor. We show that the compound reduces affinity for PI3KA relative to the PI3K inhibitor, is slow to intercellularly oxidize, and is resistant to liver microsomes. We observed modest activity in untreated acute myeloid leukemia cells and 14-fold selectivity relative to non-cancerous cells. The cellular activity of the compound can be modulated by the addition of antioxidants or oxidants, indicating the compound activity is sensitive to cellular reactive oxygen species (ROS) state. Co-treatment with cytosine arabinoside or doxorubicin was used to activate the compound inside cells. We observed strong synergistic activity specifically in acute myeloid leukemia (AML) cancer cells with an increase in selective anticancer activity of up to 90-fold. Thus, these new self-cyclizing compounds can be used to increase the selectivity of anticancer agents.
