Absorption and bioavailability of Cefditoren (cas 104145-95-1) pivoxil in hydrogels in vitro and in vivo
-
Add time:08/02/2019 Source:sciencedirect.com
Superporous gastro-retentive Cefditoren (cas 104145-95-1) pivoxil tablets were prepared to improve the absorption and bioavailability of this drug and evaluated by varying the concentrations of carbopol and sodium carboxymethyl cellulose. The pre-compression and post-compression parameters were within acceptable pharmacopoeial limits. The swelling index indicates that formulations prepared with sodium carbonate have good porosity. The dissolution behaviour in vitro showed that the formulations that contained carbopol (100 mg) and sodium carboxymethyl cellulose (60 mg) had good controlled release (94.5%) by 24 h. Studies to evaluate the pharmacokinetics in vivo showed better bioavailability, area under the concentration–time curve, elimination rate constant and half-life than a commercially available conventional dosage form.
We also recommend Trading Suppliers and Manufacturers of Cefditoren (cas 104145-95-1). Pls Click Website Link as below: cas 104145-95-1 suppliers
Prev:Efficacy and safety of Cefditoren (cas 104145-95-1) pivoxil for exacerbations of chronic obstructive pulmonary disease: A prospective multicenter interventional study
Next:Molecular Mechanisms of Biliary Excretion of Cefditoren (cas 104145-95-1) and the Effects of Cefditoren (cas 104145-95-1) on the Expression Levels of Hepatic Transporters) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- PEPT1 involved in the uptake and transepithelial transport of Cefditoren (cas 104145-95-1) in vivo and in vitro08/06/2019
- Formulation evaluation and stability studies of hydrogel tablets containing Cefditoren (cas 104145-95-1) Pivoxil08/05/2019
- Electrochemistry of Cefditoren (cas 104145-95-1) pivoxil and its voltammetric determination08/04/2019
- Molecular Mechanisms of Biliary Excretion of Cefditoren (cas 104145-95-1) and the Effects of Cefditoren (cas 104145-95-1) on the Expression Levels of Hepatic Transporters08/03/2019
- Efficacy and safety of Cefditoren (cas 104145-95-1) pivoxil for exacerbations of chronic obstructive pulmonary disease: A prospective multicenter interventional study08/01/2019
-
Health and Chemical more >
-
Related Products