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Cas Database |
| Name |
(+/-)-Verapamil hydrochloride |
EINECS | 205-800-5 |
| CAS No. | 152-11-4 | Density | 1.058g/cm3 |
| PSA | 63.95000 | LogP | 5.89508 |
| Solubility | water: >30 mg/mL | Melting Point |
142 °C (dec.)(lit.) |
| Formula | C27H38N2O4.HCl | Boiling Point | 586.1 °C at 760 mmHg |
| Molecular Weight | 491.071 | Flash Point | 308.3 °C |
| Transport Information | UN 2811 6.1/PG 3 | Appearance | white to off-white powder |
| Safety | 45-36/37/39-36/37 | Risk Codes | 25-23/24/25 |
| Molecular Structure |
|
Hazard Symbols |
 T
|
| Synonyms |
Benzeneacetonitrile,a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-,monohydrochloride (9CI);Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-,monohydrochloride (8CI);Akilen;Anpec;Apoacor;Arapamyl;Berkatens;Calan SR;Calaptin 240SR;Calaptin 80;Cardiabeltin;Civicor Retard;Cordilox;Dignover;Dilacoran HTA;Finoptin; |
Article Data | 8 |
(+/-)-Verapamil hydrochloride Chemical Properties
Product Name: Verapamil hydrochloride (CAS NO.152-11-4)
IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
Molecular Formula: C27H39ClN2O4
Molecular Weight: 491.062560 g/mol
Appearance: odorless white solid
Melting Point: 142 °C (dec.)(lit.)
Boiling Point: 586.1 °C at 760 mmHg
Flash Point: 308.3 °C
Water solubility: >30 mg/mL
Merck: 13,10012
EINECS: 205-800-5
Product Categories: Miscellaneous Biochemicals; Organics; Calcium channel
(+/-)-Verapamil hydrochloride Uses
Verapamil hydrochloride (CAS NO.152-11-4) is primarily for the treatment of paroxysmal supraventricular tachycardia, also used the treatment of angina, hypertension, and hypertrophic cardiomyopathy infarction.
(+/-)-Verapamil hydrochloride Toxicity Data With Reference
| 1. | cyt-hmn:lyms 30 µmol/L | MUREAV Mutation Research. 244 (1990),135. | ||
| 2. | orl-man TDLo:26 mg/kg:CVS,PUL | HUTODJ Human Toxicology. 4 (1985),327. | ||
| 3. | orl-man TDLo:143 µg/kg/4H-C:CVS | ICMED9 Intensive Care Medicine. 8 (1982),55. | ||
| 4. | ivn-man LDLo:256 µg/kg/1H-I:CVS | AEMED3 Annals of Emergency Medicine. 14 (1985),159. | ||
| 5. | ivn-man TDLo:71 µg/kg/5M-C | SMJOAV Southern Medical Journal. 75 (1982),1429. | ||
| 6. | orl-wmn TDLo:135 mg/kg:EYE,PUL | AJCDAG American Journal of Cardiology. 58 (1986),1142. | ||
| 7. | ivn-wmn TDLo:200 µg/kg/15S-C:CVS,PUL | NYSJAM New York State Journal of Medicine. 83 (1983),1181. | ||
| 8. | orl-inf TDLo:80 mg/kg | PEDIAU Pediatrics. 73 (1984),543. | ||
| 9. | ivn-inf TDLo:1026 µg/kg:CVS | ADCHAK Archives of Disease in Childhood. 58 (1983),465. | ||
| 10. | orl-rat LD50:108 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),766. | ||
(+/-)-Verapamil hydrochloride Safety Profile
Safety Information of Verapamil hydrochloride (CAS NO.152-11-4):
Hazard Codes:T 
Risk Statements:25-23/24/25
Safety Statements:45-36/37/39-36/37
RIDADR:UN 2811 6.1/PG 3
WGK Germany:3
RTECS:YV8320000
F:8-10
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects; arrhythmias, cardiomyopathy, coma, cyanosis, dyspnea, fall in blood pressure, mydriasis, pulse rate decrease. Human reproductive effects: impotence. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.
(+/-)-Verapamil hydrochloride Specification
Verapamil hydrochloride , its CAS NO. is 152-11-4, the synonyms are (+/-)-Verapamil hydrochloride ; 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-valeronitril ; Cordilox ; Finoptin ; Iproveratrilhydrochloride ; Izoptinhydrochloride .
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