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- (1R,2R)-( )1,2-Diphenylethylenediamine
- (1R,2R)-(-)-1,2-Diaminocyclohexane
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Cas Database |
| Name |
(1R,2R)-(-)-1,2-Diaminocyclohexane |
EINECS | 211-776-7 |
| CAS No. | 20439-47-8 | Density | 0.939 g/cm3 |
| PSA | 52.04000 | LogP | 1.61560 |
| Solubility | miscible | Melting Point |
41-45 °C |
| Formula | C6H14N2 | Boiling Point | 193.6 °C at 760 mmHg |
| Molecular Weight | 114.191 | Flash Point | 75 °C |
| Transport Information | UN 3259 8/PG 2 | Appearance | white to light yellow crystal powder |
| Safety | 26-36/37/39-45 | Risk Codes | 34 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
(1R,2R)-(-)-1,2-diaminocyclohexane acid;(1R,2R)-(-)-1,2-diamino cyclohexane;(1R, 2R)-2-Benzylamino-1-cyclopentanol;(R,R)-1,2-diaminocyclohexane;(1R,2R)-Cyclohexane-1,2-diamine;(1R,2R)-1,2-diaminocyclohexane; |
Article Data | 65 |
(1R,2R)-(-)-1,2-Diaminocyclohexane Synthetic route
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water | 98% |
| With sodium hydroxide In dichloromethane; water at 20℃; for 0.5h; Inert atmosphere; | 96% |
| With potassium hydroxide In water | 92% |
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 1034.32 Torr; for 60h; | 97% |
- 329321-24-6
((1R,2R)-2-Azido-cyclohexyl)-((R)-1-phenyl-ethyl)-amine
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With hydrogen; palladium dihydroxide In methanol at 20℃; under 2068.59 Torr; for 48h; | 95% |
- 147-71-7
D-tartaric acid
- 1121-22-8, 1436-59-5, 20439-47-8, 21436-03-3, 41013-43-8, 694-83-7
trans-1,2-Diaminocyclohexane
A
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| In water at 70℃; Resolution of racemate; optical yield given as %ee; | A n/a B 95% |
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water pH=9; | 92.9% |
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at -10 - -5℃; for 1h; | 92% |
- 1121-22-8, 1436-59-5, 20439-47-8, 21436-03-3, 41013-43-8, 694-83-7
trans-1,2-Diaminocyclohexane
- 108-59-8
malonic acid dimethyl ester
A
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
B
- 21436-03-3
(S,S)-1,2-diaminocyclohexane
C
- 186144-56-9
N-[(1R,2R)-2-(2-Methoxycarbonyl-acetylamino)-cyclohexyl]-malonamic acid methyl ester
| Conditions | Yield |
|---|---|
| With Candida antarctica lipase on acrylic resin In 1,4-dioxane at 20℃; | A n/a B n/a C 48% D n/a |
- 1121-22-8, 1436-59-5, 20439-47-8, 21436-03-3, 41013-43-8, 694-83-7
trans-1,2-Diaminocyclohexane
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
| Conditions | Yield |
|---|---|
| With L-Tartaric acid |
- 694-83-7
1,2-diaminocyclohexane
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
- 1121-22-8, 1436-59-5, 20439-47-8, 21436-03-3, 41013-43-8, 694-83-7
trans-1,2-Diaminocyclohexane
- 108-59-8
malonic acid dimethyl ester
A
- 20439-47-8
(1R,2R)-1,2-diaminocyclohexane
B
- 21436-03-3
(S,S)-1,2-diaminocyclohexane
C
- 186144-56-9
N-[(1R,2R)-2-(2-Methoxycarbonyl-acetylamino)-cyclohexyl]-malonamic acid methyl ester
| Conditions | Yield |
|---|---|
| With immobilised Candida antarctica lipase (NOVOZYM 435) In 1,4-dioxane for 7h; |
(1R,2R)-(-)-1,2-Diaminocyclohexane Chemical Properties
IUPAC Name: (1R,2R)-Cyclohexane-1,2-diamine
Synonyms of (1R,2R)-(-)-1,2-Diaminocyclohexane (CAS NO.20439-47-8): (-)-R,R-1,2-Diaminocyclohexane ; (1R,2R)-1,2-Cyclohexanediamine ; (1R,2R)-Cyclohexan-1,2-diamin ;(1R,2R)-Cyclohexane-1,2-diamine ; (R,R)-DACH
Molecular Structure: 
Molecular Formula: C6H14N2
Molecular Weight: 114.19
CAS NO: 20439-47-8
H bond acceptors: 2
H bond donors: 4
Freely Rotating Bonds: 2
Polar Surface Area: 6.48 Å2
Index of Refraction: 1.483
Molar Refractivity: 34.77 cm3
Molar Volume: 121.5 cm3
Surface Tension: 37 dyne/cm
Density: 0.939 g/cm3
Flash Point: 75 °C
Enthalpy of Vaporization: 42.98 kJ/mol
Boiling Point: 193.6 °C at 760 mmHg
Vapour Pressure: 0.46 mmHg at 25°C
Melting point: 41-45 °C
Storage temp: 2-8°C
Sensitive: Air Sensitive
Appearance: white to light yellow crystal powder
SMILES: N[C@@H]1CCCC[C@H]1N
InChI: InChI=1/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1
InChIKey: SSJXIUAHEKJCMH-PHDIDXHHBU
Std. InChI: InChI=1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1
Std. InChIKey: SSJXIUAHEKJCMH-PHDIDXHHSA-N
Product Categories of (1R,2R)-(-)-1,2-Diaminocyclohexane (CAS NO.20439-47-8): chiral;API intermediates;Chiral reagent;Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral chemicals;Chiral Compound;Cycloalkanes
(1R,2R)-(-)-1,2-Diaminocyclohexane Uses
(1R,2R)-(-)-1,2-Diaminocyclohexane (CAS NO.20439-47-8) is used as Chiral synthesis of a variety of reagents, oxaliplatin intermediates and epoxy curing agent.
(1R,2R)-(-)-1,2-Diaminocyclohexane Production
Raw materials: Acetic acid glacial-->Potassium hydroxide -->tert-Butyl methyl ether-->L(+)-Tartaric acid-->D-Tartaric acid-->3-Methylbenzoyl chloride-->(+/-)-trans-1,2-Diaminocyclohexane
(1R,2R)-(-)-1,2-Diaminocyclohexane Safety Profile
Hazard Codes: 
C
Risk Statements: 34
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3259 8/PG 2
WGK Germany: 3
F: 10-34
HazardClass: 8
PackingGroup: III
(1R,2R)-(-)-1,2-Diaminocyclohexane Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible solid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under nitrogen.
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