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(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

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(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

EINECS 211-938-7
CAS No. 716-61-0 Density 1.41 g/cm3
Solubility Melting Point 163-165 °C(lit.)
Formula C9H12N2O4 Boiling Point 451.9 °C at 760 mmHg
Molecular Weight 212.10 Flash Point 227.1 °C
Transport Information UN 3259 8/PG 3 Appearance light yellow powder
Safety 26-45-53 Risk Codes 22-36/37/38-45
Molecular Structure Molecular Structure of 716-61-0 ((1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol) Hazard Symbols HarmfulXn, ToxicT
Synonyms

1,3-Propanediol,2-amino-1-(p-nitrophenyl)-, D-threo-(-)- (8CI);(-)-threo-1-(p-Nitrophenyl)-2-amino-1,3-propanediol;(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;1,3-Propanediol,2-amino-1-(4-nitrophenyl)-, [R-(R*,R*)]-;(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;(1R,2R)-threo-(-)-1-(4-Nitrophenyl)-2-amino-1,3-propanediol;Chloramphenicol D base;Chloramphenicol base;D-(-)-threo-1-p-Nitrophenyl-2-amino-1,3-propanediol;D-1-(p-Nitrophenyl)-2-aminopropane-1,3-diol;D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol;D-threo-(1R,2R)-1-p-Nitrophenyl-2-amino-1,3-propanediol;D-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol;

 

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Chemical Properties

Empirical Formula: C9H12N2O4
Molecular Weight: 212.2026 g/mol
EINECS: 211-938-7 
Index of Refraction: 1.63
Density: 1.41 g/cm3
Flash Point: 227.1 °C
Melting point: 163-165 °C(lit.)
Storage tempreture: -20 °C
Appearance: Light yellow powder
Enthalpy of Vaporization: 74.93 kJ/mol
Boiling Point: 451.9 °C at 760 mmHg
Vapour Pressure: 5.92E-09 mmHg at 25 °C
Structure of (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (CAS NO.716-61-0):
                         
IUPAC Name: (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol
Product Categories: Amino Alcohols;Chiral Building Blocks;Synthetic Organic Chemistry;Antibiotics;Reagents and Supplements

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Uses

 (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (CAS NO.716-61-0) is used in the pharmaceutical industry, and is the intermediate of chloramphenicol .

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Production

 (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (CAS NO.716-61-0) can be derived from right-nitro-α-acetyl-amino-β-hydroxy-acetone by the reduction, hydrolysis, neutralization, and split.

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 300mg/kg (300mg/kg)   Therapie. Vol. 22, Pg. 1405, 1967.
rat LD50 subcutaneous 1900mg/kg (1900mg/kg)   Therapie. Vol. 22, Pg. 1405, 1967.

 (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (CAS NO.716-61-0) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Safety Profile

Hazard Codes: HarmfulXn,ToxicT
Risk Statements: 22-36/37/38-45 
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R45:May cause cancer.
Safety Statements: 26-45-53 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use.

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol Specification

 (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol , its cas register number is 716-61-0. It also can be called D-(-)Threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol ; Levoamine ; and Chloramphenicol base . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product:  Wash mouth out with water, and get medical aid immediately.
In addition, (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (CAS NO.716-61-0) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: oxides of nitrogen, carbon monoxide, carbon dioxide.

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