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Name	1,4-Dibromobutane	EINECS	203-775-5
CAS No.	110-52-1	Density	1.785 g/cm³
PSA	0.00000	LogP	2.55640
Solubility	immiscible with water.	Melting Point	- 20 °C(lit.)
Formula	C₄H₈Br₂	Boiling Point	197 °C at 760 mmHg
Molecular Weight	215.916	Flash Point	65.2 °C
Transport Information	UN 2810 6.1/PG 3	Appearance	Clear, colorless liquid
Safety	26-39-45-37/39	Risk Codes	25-37/38-41-36/37/38
Molecular Structure		Hazard Symbols	T,Xi,C
Synonyms	1,4-Dibrombutan;DBB;1,4 Dibromo Butane;1,4-Butylene Bromide;1,4-Dibromobutane / Tetramethylene Dibromide;1,4-Dibromobutene;Tetramethylene dibromide;Butane, 1,4-dibromo-;Butane,1,4-dibromo-;	Article Data	96

1,4-Dibromobutane Synthetic route

: 109-99-9
tetrahydrofuran

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation;	95%
With carbon tetrabromide; triphenylphosphine In chloroform at 20℃; for 240h;	93%
With 2,2,2-tribromo-1,3,2-benzodioxaphosphole In chloroform	86%

: 7051-34-5
cyclopropylcarbinyl bromide

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With water; boron tribromide In dichloromethane at 23℃; for 23h; regioselective reaction;	87%
With hydrogen bromide at 170℃; im Rohr;

: 109-99-9
tetrahydrofuran

A: 110-52-1
1,4-dibromo-butane

B: 42023-34-7
4-bromobutyl phosphite

Conditions

Conditions	Yield
With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h;	A 85% B 4%
With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h;	A 27% B 53%

: 110-63-4
Butane-1,4-diol

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With sulfuric acid; sodium bromide In water for 3h; Heating;	84.8%
With hydrogen bromide at 130℃;
With sulfuric acid; hydrogen bromide

: 150-76-5
4-methoxy-phenol

A: 110-52-1
1,4-dibromo-butane

B: 2033-83-2
1-(4-methoxyphenoxy)-4-bromobutane

Conditions

Conditions	Yield
	A n/a B 82%

: 873988-92-2
1,4-bis-isopentyloxy-butane

A: 110-52-1
1,4-dibromo-butane

B: 51748-48-2
1-bromo-4-isopentyloxy-butane

Conditions

Conditions	Yield
With hydrogen bromide

: 2516-33-8
Cyclopropylmethanol

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With hydrogen bromide

: 1200-03-9
4-bromophenyl butyl ether

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With hydrogen bromide

: 3459-88-9
1,4-diphenoxybutane

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With hydrogen bromide
With hydrogen bromide at 130 - 140℃; im Rohr;

: 31991-78-3
uvariadiamide

: 110-52-1
1,4-dibromo-butane

Conditions

Conditions	Yield
With phosphorus pentabromide
With bromine; phosphorus trichloride
With phosphorus pentabromide im Vakuum;

1,4-Dibromobutane Consensus Reports

Reported in EPA TSCA Inventory.

1,4-Dibromobutane Specification

1. Introduction of 1,4-Dibromobutane
1,4-Dibromobutane is a kind of Pharmaceutical intermediates, it is also called Dibromobutane; tetramethylene bromide; Tetramethylene dibromide.

2. Properties of 1,4-Dibromobutane
Melting Point: - 20 °C(lit.)
Boiling Point: 197 °C at 760 mmHg
Flash Point: 65.2 °C
Solubility: immiscible with water.
Appearance: Clear, colorless liquid

3. Toxicity of 1,4-Dibromobutane

1.		mmo-sat 10 µmol/plate		MUREAV Mutation Research. 141 (1984),11.
2.		ipr-mus LD50:300 mg/kg		ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),668.

4. Safety Information of 1,4-Dibromobutane
Hazard Codes :

Xi,

C (Toxic;Irritant;Corrosive)
Risk Statements :25-41-36/37/38 (Toxic if swallowed ;Risk of serious damage to eyes ;Irritating to eyes, respiratory system and skin )
Safety Statements :26-45-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;Wear suitable gloves and eye/face protection )
RIDADR :UN 2810 6.1/PG 3
WGK Germany : 2
RTECS : EJ7565000

6. Preparation of 1,4-Dibromobutane
1,4-Dibromobutane can be from THF via the open-loop, bromide derived. added hydrobromic acid,then add THF dropwise under stirring , and then dropping sulfuric acid,the temperature should be controlled at below 50 ℃. And then heated to 108 ℃ or so back 4h, after reaction continue stiring for 1h,when it is cold, take the subnatant,wash to neutral with soda solution, then add anhydrous calcium chloride for drying, filtration,then it is finished.

7. Use of 1,4-DIBROMOBUTANE
1,4-DIBROMOBUTANE can be used in organic intermediates.

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