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1-Phenyl-2-thiourea

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Name 1-Phenyl-2-thiourea EINECS 203-151-2
CAS No. 103-85-5 Density 1.294 g/cm3
Solubility Melting Point 145-150 °C(lit.)
Formula C7H8N2S Boiling Point 266.7 °C at 760 mmHg
Molecular Weight 152.23 Flash Point 115.1 °C
Transport Information UN 2811 6.1/PG 1 Appearance white crystalline powder
Safety 28-36/37-45 Risk Codes 28-43
Molecular Structure Molecular Structure of 103-85-5 (1-Phenyl-2-thiourea) Hazard Symbols VeryT+
Synonyms

Thiourea,phenyl- (9CI);Urea, 1-phenyl-2-thio- (8CI);1-Phenyl-2-thiourea;1-Phenylthiourea;N-Phenylthiourea;NSC 5779;PTU;Phenylthiocarbamide;Phenylthiourea;U 6324;a-Phenylthiourea;

 

Chemistry

Product Name: 1-Phenyl-2-thiourea (103-85-5)


Molecular Formula: C7H8N2S
Molecular Weight: 152.22g/mol
Mol File: 103-85-5.mol
Appearance: white crystalline powder
Melting Point: 145-150 °C(lit.)
Boiling point: 266.7 °C at 760 mmHg
Storage Temperature: Poison room
Flash Point: 115.1 °C
Density: 1.294 g/cm3
Water Solubility: negligible
Stability: Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.
Product Categories: Benzene derivatives
Synonyms of   1-Phenyl-2-thiourea (103-85-5): 1-phenyl-2-thio-ure ; alpha-Phenylthiourea ; Fenylthiomocovina ; NCI-C02017 ; phenyl-thioure ; phenylthiourea0 ; Rcra waste number P093 ;  rcrawastenumberp093 .

Uses

 1-Phenyl-2-thiourea (103-85-5) is used in the manufacture of rodenticides and in medical genetics.It's for the production of 2 - amino-benzothiazole, 3 - methyl-benzothiazole hydrazone such as dye intermediates. Also it's used as analytical reagent.

Production

From the first with sulfuric acid aniline salt, and then carry out addition reaction of sodium cyanide with sulfur derived.

Toxicity Data With Reference

 1-Phenyl-2-thiourea (103-85-5) is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 10mg/kg (10mg/kg)   Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
rabbit LD50 oral 40mg/kg (40mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.
rat LD50 intraperitoneal 5mg/kg (5mg/kg) ENDOCRINE: HYPERGLYCEMIA Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 186, 1947.
rat LD50 oral 3mg/kg (3mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.

Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-148 ,1978. . EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Safety Profile

Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Safety Information of  1-Phenyl-2-thiourea (103-85-5):
Hazard Codes: T+
Risk Statements: 28-43
28:  Very Toxic if swallowed
43:  May cause sensitization by skin contact
Safety Statements: 28-36/37-45
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

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