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Cas Database |
| Name |
1-Phenyl-2-thiourea |
EINECS | 203-151-2 |
| CAS No. | 103-85-5 | Density | 1.294 g/cm3 |
| PSA | 70.14000 | LogP | 2.11540 |
| Solubility | Soluble in hot water and alcohol. | Melting Point |
145-150 °C(lit.) |
| Formula | C7H8N2S | Boiling Point | 266.7 °C at 760 mmHg |
| Molecular Weight | 152.22 | Flash Point | 115.1 °C |
| Transport Information | UN 2811 6.1/PG 1 | Appearance | white crystalline powder |
| Safety | 28-36/37-45 | Risk Codes | 28-43 |
| Molecular Structure |
|
Hazard Symbols |
 T+
|
| Synonyms |
Thiourea,phenyl- (9CI);Urea, 1-phenyl-2-thio- (8CI);1-Phenyl-2-thiourea;1-Phenylthiourea;N-Phenylthiourea;NSC 5779;PTU;Phenylthiocarbamide;Phenylthiourea;U 6324;a-Phenylthiourea; |
Article Data | 200 |
1-Phenyl-2-thiourea Synthetic route
| Conditions | Yield |
|---|---|
| With ammonia at -30℃; under 300.024 Torr; Addition; solid-gas reaction; | 100% |
| With ammonium hydroxide In water; acetonitrile at 20℃; for 3h; | 100% |
| With ammonia In 1,2-dimethoxyethane | 99% |
| Conditions | Yield |
|---|---|
| With hydrazine at 25℃; for 0.166667h; | 95% |
| With sodium hydroxide In water at 80℃; | 92.2% |
| With sodium hydroxide at 98℃; for 0.166667h; | 90% |
| Conditions | Yield |
|---|---|
| With ethanol for 0.0125h; Microwave irradiation; Neat (no solvent); | 94% |
| Heating; | 75% |
| With water at 100℃; Ausziehen den Salmiak durch kaltes Wasser und Umkrystallisieren das Umgeloeste aus siedendem Alkohol; |
| Conditions | Yield |
|---|---|
| Stage #1: aniline; 3-methyl-1-(methyldithiocarbonyl)imidazolium iodide In ethanol Substitution; Heating; Stage #2: With ammonia In ethanol for 3h; Substitution; | 94% |
| Conditions | Yield |
|---|---|
| With dibenzyl ether Inert atmosphere; | 91% |
| Conditions | Yield |
|---|---|
| Stage #1: ammonium thiocyanate With benzoyl chloride In acetone at 70℃; for 0.25h; Stage #2: aniline In acetone Heating; Stage #3: With sodium hydroxide at 90℃; for 0.333333h; | 82% |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; trimethylbenzylammonium bromide; triethylamine In ethyl acetate for 2.5h; Heating; | 80% |
| With ethanol; ammonia at 100℃; | |
| Multi-step reaction with 2 steps 1: hydrogen chloride 2: alcohol; ammonia View Scheme |
- 103-85-5
monophenylthiourea
| Conditions | Yield |
|---|---|
| With hydrogen sulfide In tetrahydrofuran at 90℃; for 4h; | 78% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water at 90℃; for 20h; | A 27% B 73% |
| Conditions | Yield |
|---|---|
| In acetone for 18h; Reflux; | 73% |
1-Phenyl-2-thiourea Chemical Properties
Product Name: 1-Phenyl-2-thiourea (103-85-5)
Molecular Formula: C7H8N2S
Molecular Weight: 152.22g/mol
Mol File: 103-85-5.mol
Appearance: white crystalline powder
Melting Point: 145-150 °C(lit.)
Boiling point: 266.7 °C at 760 mmHg
Storage Temperature: Poison room
Flash Point: 115.1 °C
Density: 1.294 g/cm3
Water Solubility: negligible
Stability: Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.
Product Categories: Benzene derivatives
Synonyms of 1-Phenyl-2-thiourea (103-85-5): 1-phenyl-2-thio-ure ; alpha-Phenylthiourea ; Fenylthiomocovina ; NCI-C02017 ; phenyl-thioure ; phenylthiourea0 ; Rcra waste number P093 ; rcrawastenumberp093 .
1-Phenyl-2-thiourea Uses
1-Phenyl-2-thiourea (103-85-5) is used in the manufacture of rodenticides and in medical genetics.It's for the production of 2 - amino-benzothiazole, 3 - methyl-benzothiazole hydrazone such as dye intermediates. Also it's used as analytical reagent.
1-Phenyl-2-thiourea Production
From the first with sulfuric acid aniline salt, and then carry out addition reaction of sodium cyanide with sulfur derived.
1-Phenyl-2-thiourea Toxicity Data With Reference
1-Phenyl-2-thiourea (103-85-5) is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 25mg/kg (25mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 10mg/kg (10mg/kg) | Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973, | |
| rabbit | LD50 | oral | 40mg/kg (40mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961. | |
| rat | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | ENDOCRINE: HYPERGLYCEMIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 186, 1947. |
| rat | LD50 | oral | 3mg/kg (3mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961. |
1-Phenyl-2-thiourea Consensus Reports
NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-148 ,1978. . EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
1-Phenyl-2-thiourea Safety Profile
Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Safety Information of 1-Phenyl-2-thiourea (103-85-5):
Hazard Codes: T+.gif){kind=small}
Risk Statements: 28-43
28: Very Toxic if swallowed
43: May cause sensitization by skin contact
Safety Statements: 28-36/37-45
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
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