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1-Phenyl-2-thiourea

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1-Phenyl-2-thiourea

EINECS 203-151-2
CAS No. 103-85-5 Density 1.294 g/cm3
Solubility Melting Point 145-150 °C(lit.)
Formula C7H8N2S Boiling Point 266.7 °C at 760 mmHg
Molecular Weight 152.23 Flash Point 115.1 °C
Transport Information UN 2811 6.1/PG 1 Appearance white crystalline powder
Safety 28-36/37-45 Risk Codes 28-43
Molecular Structure Molecular Structure of 103-85-5 (1-Phenyl-2-thiourea) Hazard Symbols VeryT+
Synonyms

Thiourea,phenyl- (9CI);Urea, 1-phenyl-2-thio- (8CI);1-Phenyl-2-thiourea;1-Phenylthiourea;N-Phenylthiourea;NSC 5779;PTU;Phenylthiocarbamide;Phenylthiourea;U 6324;a-Phenylthiourea;

 

1-Phenyl-2-thiourea Chemical Properties

Product Name: 1-Phenyl-2-thiourea (103-85-5)


Molecular Formula: C7H8N2S
Molecular Weight: 152.22g/mol
Mol File: 103-85-5.mol
Appearance: white crystalline powder
Melting Point: 145-150 °C(lit.)
Boiling point: 266.7 °C at 760 mmHg
Storage Temperature: Poison room
Flash Point: 115.1 °C
Density: 1.294 g/cm3
Water Solubility: negligible
Stability: Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.
Product Categories: Benzene derivatives
Synonyms of   1-Phenyl-2-thiourea (103-85-5): 1-phenyl-2-thio-ure ; alpha-Phenylthiourea ; Fenylthiomocovina ; NCI-C02017 ; phenyl-thioure ; phenylthiourea0 ; Rcra waste number P093 ;  rcrawastenumberp093 .

1-Phenyl-2-thiourea Uses

 1-Phenyl-2-thiourea (103-85-5) is used in the manufacture of rodenticides and in medical genetics.It's for the production of 2 - amino-benzothiazole, 3 - methyl-benzothiazole hydrazone such as dye intermediates. Also it's used as analytical reagent.

1-Phenyl-2-thiourea Production

From the first with sulfuric acid aniline salt, and then carry out addition reaction of sodium cyanide with sulfur derived.

1-Phenyl-2-thiourea Toxicity Data With Reference

 1-Phenyl-2-thiourea (103-85-5) is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 oral 10mg/kg (10mg/kg)   Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
rabbit LD50 oral 40mg/kg (40mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.
rat LD50 intraperitoneal 5mg/kg (5mg/kg) ENDOCRINE: HYPERGLYCEMIA Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 186, 1947.
rat LD50 oral 3mg/kg (3mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 4, Pg. 109, 1961.

1-Phenyl-2-thiourea Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-148 ,1978. . EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

1-Phenyl-2-thiourea Safety Profile

Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.
Safety Information of  1-Phenyl-2-thiourea (103-85-5):
Hazard Codes: T+
Risk Statements: 28-43
28:  Very Toxic if swallowed
43:  May cause sensitization by skin contact
Safety Statements: 28-36/37-45
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

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