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Name |
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)- |
EINECS | 200-495-5 |
CAS No. | 60-99-1 | Density | 1.125 g/cm3 |
PSA | 41.01000 | LogP | 4.56060 |
Solubility | 20mg/L(25 oC) | Melting Point |
117°C |
Formula | C19H24N2OS | Boiling Point | 468 °C at 760 mmHg |
Molecular Weight | 328.478 | Flash Point | 236.8 °C |
Transport Information | UN 3249 | Appearance | N/A |
Safety | 36 | Risk Codes | 20/21/22 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
10H-Phenothiazine-10-propanamine,2-methoxy-N,N,b-trimethyl-,(R)-;Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)-(8CI);2-Methoxytrimeprazine;7044 R.P.;CL 36467;CL 39743;Hirnamin;Levomeprazine;Levomepromazin;Levomepromazine;Levopromazine;Levoprome;Levopromethazine;Levotomin;Mepromazine;Methotrimeprazine;NSC 226516;Neozine;Nirvan;Nozinan;Nozinane;RP 7044;SKF 5116;Sinogan;Sinogan-Debil;Tisercin;XP 03; |
Conditions | Yield |
---|---|
With D-tartaric acid |
(S)-γ-(2-methoxy-phenothiazin-10-yl)-isobutylamin; hydrochloride
levomepromazine
Conditions | Yield |
---|---|
anschliessende Hydrierung an Platin; |
This chemical is called 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)-, and its CAS registry number is 60-99-1. With the molecular formula of C19H24N2OS, its classification codes are Analgesic; Analgesic [central nervous system depressant]; Analgesics, non-narcotic; Central Nervous System Depressants; Dopamine Agents; Dopamine antagonists; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Psychotropic Drugs; Sensory System Agents; Tranquilizing Agents. Additionally, its product categories are Intermediates & Fine Chemicals; Pharmaceuticals. It's a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine.
Other characteristics of the 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-, (βR)- can be summarised as followings: (1)ACD/LogP: 4.94; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.91; (4)ACD/LogD (pH 7.4): 3.04; (5)ACD/BCF (pH 5.5): 3.15; (6)ACD/BCF (pH 7.4): 42.18; (7)ACD/KOC (pH 5.5): 10.94; (8)ACD/KOC (pH 7.4): 146.34; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 41.01 Å2; (13)Index of Refraction: 1.594; (14)Molar Refractivity: 99.12 cm3; (15)Molar Volume: 291.8 cm3; (16)Polarizability: 39.29×10-24cm3; (17)Surface Tension: 42.7 dyne/cm; (18)Density: 1.125 g/cm3; (19)Flash Point: 236.8 °C; (20)Enthalpy of Vaporization: 73.01 kJ/mol; (21)Boiling Point: 468 °C at 760 mmHg; (22)Vapour Pressure: 6.22E-09 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following: This chemical is harmful by inhalation, in contacting with skin and if swallowed. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: O(c2cc1N(c3c(Sc1cc2)cccc3)C[C@H](C)CN(C)C)C
2.InChI: InChI=1/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1
3.InChIKey: VRQVVMDWGGWHTJ-CQSZACIVBE
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 100mg/kg (100mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
man | TDLo | oral | 7143ug/kg (7.143mg/kg) | BLOOD: THROMBOCYTOPENIA | Human Psychopharmacology. Vol. 9, Pg. 299, 1994. |
mouse | LD50 | intraperitoneal | 58500ug/kg (58.5mg/kg) | Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990. | |
mouse | LD50 | intravenous | 39mg/kg (39mg/kg) | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 9, Pg. 159, 1968. | |
mouse | LD50 | oral | 370mg/kg (370mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 841, 1965. | |
mouse | LD50 | subcutaneous | 300mg/kg (300mg/kg) | Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963. | |
rat | LD50 | oral | 1100mg/kg (1100mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 31, 1972. | |
rat | LD50 | subcutaneous | 45mg/kg (45mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 31, 1972. |