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2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
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Name

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine

 EINECS 1806241-263-5
CAS No. 122368-54-1 Density 1.217 g/cm3
PSA 34.15000 LogP 3.92180
Solubility N/A Melting Point N/A
Formula C17H19ClN2O Boiling Point 421.68 °C at 760 mmHg
Molecular Weight 302.804 Flash Point 208.825 °C
Transport Information N/A Appearance Brown Viscous liquid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 122368-54-1 (2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine) Hazard Symbols N/A
Synonyms

(RS)-4-[(4-Chlorophenyl)(2-pyridyl)methoxy]piperidine;

Article Data 7

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Synthetic route

4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine fumaric acid salt

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane at 20℃; for 0.166667h;99%
With sodium hydroxide In dichloromethane86.6%

2-((1-benzylpiperidin-4-yloxy)(4-chlorophenyl)methyl)pyridine

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
With 5%-palladium/activated carbon In methanol at 30℃; under 2068.65 Torr; for 4h; Inert atmosphere; Autoclave;94%
78539-93-2

3-(4-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine

109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Stage #1: 3-(4-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine; t-butyl 4-hydroxy piperidine-1-carboxylate With potassium carbonate In benzene at 20℃; for 10h; UV-irradiation;
Stage #2: With trifluoroacetic acid at 20℃; for 1h;		71%
27652-89-7

(4-chlorophenyl)-2-pyridylmethanol

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / toluene / 1 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine / 3 h / 80 °C
3: sodium hydroxide / isopropyl alcohol / 12 h / Reflux
4: 5 h / 20 °C
5: sodium hydroxide / dichloromethane / 0.17 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Reflux
2: 5%-palladium/activated carbon / methanol / 4 h / 30 °C / 2068.65 Torr / Inert atmosphere; Autoclave
View Scheme

C13H12ClNO3S

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / 3 h / 80 °C
2: sodium hydroxide / isopropyl alcohol / 12 h / Reflux
3: 5 h / 20 °C
4: sodium hydroxide / dichloromethane / 0.17 h / 20 °C
View Scheme
207726-35-0

4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine-1-carboxylic acid ethyl ester

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / isopropyl alcohol / 12 h / Reflux
2: 5 h / 20 °C
3: sodium hydroxide / dichloromethane / 0.17 h / 20 °C
View Scheme
With isopropyl alcohol; sodium hydroxide at 88℃; for 6h;

C18H19ClN2O3

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5 h / 20 °C
2: sodium hydroxide / dichloromethane / 0.17 h / 20 °C
View Scheme
4045-22-1

N-acetyl-4-hydroxypiperidine

142404-69-1

2-(chloro(4-chlorophenyl)methyl)pyridine

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Stage #1: N-acetyl-4-hydroxypiperidine; 2-[chloro(4-chlorophenyl)methyl]pyridine at 130℃; for 5h; Large scale;
Stage #2: With hydrogenchloride In water at 80℃; for 15h; Large scale;
5382-16-1

4-HYDROXYPIPERIDINE

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 1 h / -70 °C / Large scale
1.2: 20 °C / Large scale
2.1: 5 h / 130 °C / Large scale
2.2: 15 h / 80 °C / Large scale
View Scheme
109-04-6

2-bromo-pyridine

122368-54-1

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere
1.2: 4 h / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Reflux
3.1: 5%-palladium/activated carbon / methanol / 4 h / 30 °C / 2068.65 Torr / Inert atmosphere; Autoclave
View Scheme

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Chemical Properties

Molecular Structure of 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (CAS NO.122368-54-1):

Systematic Name: 2-[(4-Chlorophenyl)(piperidin-4-yloxy)methyl]pyridine 
Molecular Formula: C17H19ClN2O
Molecular Weight: 302.80 
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 4
Nominal Mass: 302
Average Mass: 302.7986
Monoisotopic Mass: 302.118591
Index of Refraction: 1.601
Molar Refractivity: 85.178 cm3
Molar Volume: 248.708 cm3
Surface Tension: 51.295 dyne/cm
Density: 1.217 g/cm3
Flash Point: 208.825 °C
Enthalpy of Vaporization: 67.573 kJ/mol
Boiling Point: 421.68 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C
SMILES: Clc1ccc(cc1)C(OC2CCNCC2)c3ncccc3
InChI: InChI=1/C17H19ClN2O/c18-14-6-4-13(5-7-14)17(16-3-1-2-10-20-16)21-15-8-11-19-12-9-15/h1-7,10,15,17,19H,8-9,11-12H2
InChIKey: OTZYADIPHOGUDN-UHFFFAOYAW

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine Specification

 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (CAS NO.122368-54-1), its Synonyms are Pyridine,2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]- ; (RS)-4-[(4-Chlorophenyl)(2-pyridyl)methoxy]piperidine .

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