2--AMINOETHYLISOTHIOUREA (56-10-0),2--AMINOETHYLISOTHIOUREA (56-10-0) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Carbamimidothioic acid,2-aminoethyl ester, hydrobromide (1:2)
Superlist Name:
2-(2-Aminoethyl)isothiourea dihydrobromide
CAS No.:
56-10-0
Molecular Structure:
Formula:
C₃H₉N₃S^.₂HBr
Molecular Weight:
281.05
Synonyms:
Carbamimidothioicacid, 2-aminoethyl ester, dihydrobromide (9CI);Pseudourea, 2-(2-aminoethyl)-2-thio-,dihydrobromide (8CI);2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide;2-(2-Aminoethyl)-2-thiopseudourea hydrobromide;2-(b-Aminoethyl)isothiuronium bromide hydrobromide;AET;Antiradon;Ixecur;NSC 22877;S-(2-Aminoethyl)isothiuronium bromidehydrobromide;S-(b-Aminoethyl)isothiuroniumbromide hydrobromide;Surrectan;
EINECS:
200-257-0
Melting Point:
190-196 °C(lit.)
Boiling Point:
231.1 °C at 760 mmHg
Flash Point:
93.6 °C
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38
Safety Description:
26-36/37-22 Details

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Chemistry

Chemical Name: 2-(2-Aminoethyl)isothiourea dihydrobromide
IUPAC NAME: 2-aminoethyl carbamimidothioate dihydrobromide
CAS No.: 56-10-0
EINECS: 200-257-0
RTECS: UM0175000
Molecular Formula: C₃H₁₁Br₂N₃S
Molecular Weight: 281.01 g/mol
Melting Point: 190-196 °C(lit.)
Flash Point: 93.6 °C
Boiling Point: 231.1 °C at 760 mmHg
Following is the structure of 2-β-AMINOETHYLISOTHIOUREA(56-10-0):

The chemical synonymous of 2-β-AMINOETHYLISOTHIOUREA(56-10-0) are (2-aminoethyl)-2-thio-pseudouredihydrobromide;2-(2-aminoethyl)-2-thiopseudoureahydrobromide;2-(beta-aminoethyl)isothiouroniumbromidehydrobromide;2-aminoethylisothiourea;2-aminoethylisothioureahydrobromide;2-aminoethylisothiouroniumdibromide;2-aminoethylisothiuroniumbromidehydrobromide;2-aminoethylisothiuroniumdihydrobromide.

Uses

2-β-AMINOETHYLISOTHIOUREA(56-10-0) is used in organic synthesis, enzyme activator, radiation, disease prevention, free radical antidote.The product as a drug can promote brain cell metabolism, increase the use of carbohydrates to enhance excitability. Patients with traumatic coma can quickly restore the brain's functions, and confrontation in central inhibition of drug effect. Applies to traumatic coma, cardiovascular diseases caused by coma, carbon monoxide poisoning, and stability drugs barbiturate poisoning, radiation injury and cerebral hypoxia and so on.

Toxicity Data With Reference

dog	LD50	intraperitoneal	113mg/kg (113mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
dog	LD50	oral	177mg/kg (177mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
guinea pig	LD50	intraperitoneal	356mg/kg (356mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse	LD50	intraperitoneal	400mg/kg (400mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	85400ug/kg (85.4mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse	LD50	oral	815mg/kg (815mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 218, 1960.
mouse	LD50	subcutaneous	242mg/kg (242mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 576, 1957.
rabbit	LD50	intraperitoneal	236mg/kg (236mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 510, 1963.
rat	LD50	intraperitoneal	288mg/kg (288mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 142, Pg. 198, 1963.
rat	LD50	intravenous	85mg/kg (85mg/kg)		Casopis Lekaru Ceskych. Journal of Czech Physicians. Vol. 105, Pg. 1165, 1966.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic NO_x, SO_x, and HBr.
Hazard Codes:
Xn: Harmful

Risk Statements about 2-β-AMINOETHYLISOTHIOUREA(56-10-0):
    R22 Harmful if swallowed.
    R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about 2-β-AMINOETHYLISOTHIOUREA(56-10-0):
    S22 Do not breathe dust.
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S36/37: Wear suitable protective clothing and gloves.