Basic information
- Name:
2(1H)-Pyridinone,5-methyl-1-phenyl-
- Superlist Name:
- Pirfenidone
- CAS No.:
53179-13-8
- Molecular Structure:
- Formula:
- C12H11NO
- Molecular Weight:
- 185.22
- Synonyms:
- 5-Methyl-1-phenyl-1H-pyridin-2-one;5-Methyl-1-phenyl-2(1H)-pyridinone;5-Methyl-1-phenyl-2(1H)-pyridone;AMR 69;Deskar;Pirespa;Pirfenidone;
- Density:
- 1.138 g/cm3
- Melting Point:
- 96-97 °C
- Boiling Point:
- 329.075 °C at 760 mmHg
- Flash Point:
- 152.741 °C
- Solubility:
- DMSO: ≥10 mg/mL, soluble
- Appearance:
- Off-white solid
- Hazard Symbols:
Xn- Risk Codes:
- 22
- Safety Description:
- 36 Details
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Chemistry
IUPAC Name: 5-Methyl-1-phenylpyridin-2-one
Systematic of 2(1H)-Pyridinone,5-methyl-1-phenyl- (CAS NO.53179-13-8): Pirfenidone [USAN:INN] ; 5-21-07-00197 (Beilstein Handbook Reference) ; 5-Methyl-1-phenyl-2(1H)-pyridone ; AMR 69 ; AMR-69 ; BRN 1526549 ; Deskar ; Pirespa ; Pirfenidona ; Pirfenidona [INN-Spanish] ; Pirfenidone ; Pirfenidonum ; Pirfenidonum [INN-Latin] ; UNII-D7NLD2JX7U ; 2(1H)-Pyridinone, 5-methyl-1-phenyl-
CAS NO: 53179-13-8
Classification Code: Analgesic ; Analgesics ; Analgesics, Non-Narcotic ; Anti-Inflammatory Agents ; Anti-inflammatory ; Anti-inflammatory agents, non-steroidal ; Antineoplastic agents ; Antipyretic ; Antirheumatic Agents ; Central Nervous System Agents ; Drug / Therapeutic Agent ; Peripheral Nervous System Agents ; Sensory System Agents
Molecular Formula of 2(1H)-Pyridinone,5-methyl-1-phenyl- (CAS NO.53179-13-8): C12H11NO
Molecular Weight: 185.2218
Molecular Structure:
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Melting Point: 96-97°C
H bond acceptors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 20.31 Å2
Index of Refraction: 1.592
Molar Refractivity: 55.11 cm3
Molar Volume: 162.7 cm3
Surface Tension: 43.2 dyne/cm
Density of 2(1H)-Pyridinone,5-methyl-1-phenyl- (CAS NO.53179-13-8): 1.137 g/cm3
Flash Point: 152.7 °C
Enthalpy of Vaporization: 57.15 kJ/mol
Boiling Point: 329.1 °C at 760 mmHg
Vapour Pressure: 0.000182 mmHg at 25°C
Uses
2(1H)-Pyridinone,5-methyl-1-phenyl- (CAS NO.53179-13-8) is used in multiple fibrotic conditions, including those of the lung, kidney and liver.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 40mg/kg (40mg/kg) | European Patent Application. Vol. #383591, | |
| cat | LD50 | oral | 500mg/kg (500mg/kg) | European Patent Application. Vol. #383591, | |
| dog | LD50 | intravenous | 200mg/kg (200mg/kg) | European Patent Application. Vol. #383591, | |
| dog | LD50 | oral | 300mg/kg (300mg/kg) | European Patent Application. Vol. #383591, | |
| guinea pig | LD50 | intraperitoneal | 460mg/kg (460mg/kg) | European Patent Application. Vol. #383591, | |
| guinea pig | LD50 | oral | 810mg/kg (810mg/kg) | European Patent Application. Vol. #383591, | |
| monkey | LD50 | intravenous | 100mg/kg (100mg/kg) | European Patent Application. Vol. #383591, | |
| mouse | LD50 | intraperitoneal | 420mg/kg (420mg/kg) | United States Patent Document. Vol. #3974281, | |
| mouse | LD50 | intravenous | 285mg/kg (285mg/kg) | European Patent Application. Vol. #383591, | |
| mouse | LD50 | oral | 580mg/kg (580mg/kg) | United States Patent Document. Vol. #4042699, | |
| rabbit | LD50 | intravenous | 280mg/kg (280mg/kg) | European Patent Application. Vol. #383591, | |
| rat | LD50 | intraperitoneal | 430mg/kg (430mg/kg) | European Patent Application. Vol. #383591, | |
| rat | LD50 | oral | 1295mg/kg (1295mg/kg) | European Patent Application. Vol. #383591, |
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22
R22: Harmful if swallowed.
Safety Statements: 36
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: UV1148200
