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Home > Hot Product_List > 2,2,3,3-Tetrafluoro-1-propanol

Basic information

  • Name:
  • 2,2,3,3-Tetrafluoro-1-propanol

  • CAS No.:
  • 76-37-9

  • Molecular Structure:
  • Formula:
  • C3H4F4O
  • Molecular Weight:
  • 132.07
  • Synonyms:
  • 1,1,3-Trihydroperfluoro-1-propanol;2,2,3,3-Tetrafluoropropyl alcohol;2,2,3,3-tetrafluoro-porpanol;1-Propanol, 2,2,3,3-tetrafluoro-;2,2,3,3-Tetrafluoropropanol-1;1,1, 3-Trihydroperfluoro-1-propanol;Tetrafluoropropyl alcohol;4-01-00-01438 (Beilstein Handbook Reference);2,2,3,3-Tetrafluoropropan-1-ol;2, 2,3,3-Tetrafluoropropyl alcohol;2,2,3,3-Tetrafluoro-1-propanol (TFP);1H,1H,3H-Tetrafluoro-1-propanol;2,2,3,3-tetrafluoro-1-propanol;;Tetrafluoropropanol;Trans-4-ethyl Hexahydrobenzoic Acid;2,2,3,3-Tetrafluoro-Propanol;2,2,3,3-Tetrafluoro-1-Propanol(Tfp);
  • EINECS:
  • 200-955-5
  • Density:
  • 1.35 g/cm3
  • Melting Point:
  • -15 °C
  • Boiling Point:
  • 109.5 °C at 760 mmHg
  • Flash Point:
  • 31 °C
  • Appearance:
  • colourless liquid
  • Hazard Symbols:
  • HarmfulXn, FlammableF, IrritantXi
  • Risk Codes:
  • 10-20-36-36/37/38
  • Safety Description:
  • 26-37/39-16-36/37-36 Details
  • Transport Information:
  • UN 1986 3/PG 3

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The 2,2,3,3-Tetrafluoro-1-propanol, with the cas registry number 76-37-9, has the systematic name of 2,2,3,3-tetrafluoropropan-1-ol. This is a kind of stable chemical, and it is incompatible with strong oxidizing agents, strong bases, sodium, potassium, acid chlorides, acid anhydrides. Its product categories are various, including industrial/fine chemicals; small molecule; organic fluorides; alcohols; c2 to c6; oxygen compounds.

The characteristics of this chemical are as follows: (1)#H bond acceptors: 1; (2)#H bond donors: 1; (3)#Freely Rotating Bonds: 3; (4)Polar Surface Area: 20.23; (5)Index of Refraction: 1.296; (6)Molar Refractivity: 18.06 cm3; (7)Molar Volume: 97.7 cm3; (8)Polarizability: 7.16 ×10-24 cm3; (9)Surface Tension: 17 dyne/cm; (10)Density: 1.35 g/cm3; (11)Flash Point: 31 °C; (12)Enthalpy of Vaporization: 40.59 kJ/mol; (13)Boiling Point: 109.5 °C at 760 mmHg; (14)Vapour Pressure: 13.1 mmHg at 25°C; (15)Exact Mass: 132.019828; (16)MonoIsotopic Mass: 132.019828; (17)Topological Polar Surface Area: 20.2; (18)Heavy Atom Count: 8; (19)Complexity: 71.7.

Use of 2,2,3,3-Tetrafluoro-1-propanol is as below:  2,2,3,3-Tetrafluoro-1-propanol could react to produce 3-chloro-1,1,2,2-tetrafluoro-propane, with the following condition: reagent: (2-chloro-1,1,2-trifluoro-ethyl)-diethyl-amin; reaction temp.: 170 ℃.

As to its usage, it is widely applied in many ways. It is usually used in pharmaceutics, intermediate for pesticide, light disk paint solvent, and cleaning agent.

When dealing with this chemical, you should be cautious and then take some measures to protect yourself. For one thing, it is irritant. This chemical is irritating to eyes, respiratory system and skin. For another thing, it is harmful, and may cause damage to health. In addition, it is highly flammable. It may catch fire in contact with air, only needing brief contact with an ignition source, and it has a very low flash point or evolve highly flammable gases in contact with water. Therefore, you should take the following instructions. Wear suitable clothing, gloves and eye/face protection, and keep away from sources of ignition - No smoking. If in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Additionally, the following data information could be converted into the molecular structure:
(1)SMILES:FC(F)C(F)(F)CO
(2)InChI:InChI=1/C3H4F4O/c4-2(5)3(6,7)1-8/h2,8H,1H2
(3)InChIKey:NBUKAOOFKZFCGD-UHFFFAOYAL

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC50 inhalation 8600mg/m3/2H (8600mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 109, 1982.
rat LCLo inhalation 2000ppm/4H (2000ppm) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Occupational Medicine. Vol. 4, Pg. 262, 1962.
rat LDLo oral 3400mg/kg (3400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Occupational Medicine. Vol. 4, Pg. 262, 1962

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