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Name	2,2,4-TRIMETHYL-1,3-PENTANEDIOL	EINECS	205-619-1
CAS No.	144-19-4	Density	0.935 g/cm³
PSA	40.46000	LogP	1.02180
Solubility	31.5g/L at 20℃	Melting Point	50-53 °C(lit.)
Formula	C₈H₁₈O₂	Boiling Point	231.999 °C at 760 mmHg
Molecular Weight	146.23	Flash Point	92.667 °C
Transport Information	N/A	Appearance	white crystalline powder
Safety	26-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	2,2,4-Trimethyl-1,3-pentanediol;NSC 6368;Nexcoat 795;TMPD (alcohol);	Article Data	44

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Synthetic route

: 77-68-9
texanol

A: 144-19-4
2,2,4-trimethylpentan-1,3-diol

B: 6846-50-0
2,2,4-trimethyl-1,3-pentanediol diisobutyrate

Conditions

Conditions	Yield
With Cr2O3/SO42 solid acid catalyst at 160℃; for 6h; Reagent/catalyst; Temperature;	A n/a B 93%

: 78-84-2
isobutyraldehyde

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
With nickel In sodium hydroxide at 20℃; Electrochemical reaction;	92%
With sodium hydroxide
With calcium hydroxide

: 74-85-1
ethene

: 78-84-2
isobutyraldehyde

: 2,4-dimethyl-1,3-pentane diol

B: 144-19-4
2,2,4-trimethylpentan-1,3-diol

C: 3876-46-8, 3876-47-9, 60712-38-1, 82335-99-7, 97906-32-6, 98391-91-4, 103729-84-6, 103729-88-0, 129262-73-3
(2R,3S)-2,4-dimethyl-1,3-pentane diol

Conditions

Conditions	Yield
Stage #1: ethene; isobutyraldehyde With carbon monoxide; hydrogen; triphenylphosphine; acetylacetonatodicarbonylrhodium(l); L-proline In N,N-dimethyl-formamide at 5℃; under 22502.3 Torr; for 48h; Stage #2: With sodium tetrahydroborate In methanol; N,N-dimethyl-formamide at 0℃; for 0.666667h; Further stages.;	A n/a B n/a C 76%

: 221319-52-4
7-Isopropyl-8,8-dimethyl-8,9-dihydro-7H-6,10-dioxabenzocyclononene-5,11-dione

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
	48%

: 16889-18-2
5,5-dimethyl-2,6-bis(propan-2-yl)-1,3-dioxan-4-ol

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
With water; nickel at 50 - 85℃; Hydrogenation;
With hydrogen; chromium nickel
Multi-step reaction with 2 steps 1: aqueous acetic acid / Abdestillieren des entstehenden Isobutyraldehyds 2: Raney nickel; water / 125 - 165 °C / Hydrogenation View Scheme

: 918-79-6
3-hydroxy-2,2,4-trimethyl-pentanal

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
With sodium amalgam; ethanol; sulfuric acid
With water; nickel at 125 - 165℃; Hydrogenation;

: 918-79-6
3-hydroxy-2,2,4-trimethyl-pentanal

A: 144-19-4
2,2,4-trimethylpentan-1,3-diol

B: 79-31-2
isobutyric Acid

Conditions

Conditions	Yield
With potassium hydroxide zuletzt bei Siedetemperatur;

: 78-84-2
isobutyraldehyde

A: 144-19-4
2,2,4-trimethylpentan-1,3-diol

B: 918-79-6
3-hydroxy-2,2,4-trimethyl-pentanal

Conditions

Conditions	Yield
With potassium hydroxide

: 563-47-3
3-Chloro-2-methylpropene

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
With sodium hydroxide at 200℃;
With water; calcium carbonate at 150℃; under 40452.9 Torr;

: 7403-65-8
ethyl 2,2,4-trimethyl-3-hydroxyvalerate

: 144-19-4
2,2,4-trimethylpentan-1,3-diol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Chemical Properties

Molecular Formula: C₈H₁₈O₂

Formula Weight: 146.23
mp : 50-53 ^°C(lit.)
bp : 232 ^°C(lit.)
density : 0,937 g/cm³
Fp : >230 ^°F
Flash Point: 125 °C ( 257.00 ^°F)
Vapor Pressure: 28 mbar @ 129 ^°C
Viscosity: 19.6 mPas 60 ^°C
Solubility in water: soluble in alcohol, acetone, ether, benz
Physical State of 2,2,4-TRIMETHYL-1,3-PENTANEDIOL (144-19-4): Crystalline Solid
Color of 2,2,4-TRIMETHYL-1,3-PENTANEDIOL (144-19-4) : white

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Uses

2,2,4-TRIMETHYL-1,3-PENTANEDIOL (144-19-4) is mainly used in the manufacture of polyester resin, coating with alkyd resin, and also used for synthetic ester in coatings, plastic as plasticizers, etc.

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Toxicity Data With Reference

1.	skn-rbt 9370 µg/24H open MLD	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
2.	orl-rat LDLo:2000 mg/kg	KODAK* Kodak Company Reports .(Rochester, NY.: ),1971.
3.	ipr-rat LDLo:800 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 29 (1974),87.
4.	ivn-rat LDLo:145 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 29 (1974),87.
5.	orl-mus LDLo:2200 mg/kg	KODAK* Kodak Company Reports .(Rochester, NY.: ),1971.
6.	ipr-mus LDLo:800 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 29 (1974),87.
7.	ivn-mus LDLo:145 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 29 (1974),87.

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Consensus Reports

Reported in EPA TSCA Inventory.

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Safety Profile

Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable gloves and eye/face protection)
WGK Germany : 1
RTECS : SA1400000
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A skin irritant. An insect repellent. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use CO₂, fog, mist, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

2,2,4-TRIMETHYL-1,3-PENTANEDIOL Specification

Handling of 2,2,4-TRIMETHYL-1,3-PENTANEDIOL (144-19-4): Keep container tightly closed. Avoid ingestion and inhalation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation.
Storage of 2,2,4-TRIMETHYL-1,3-PENTANEDIOL (144-19-4): Store in a cool, dry, well-ventilated area away from
incompatible substances. Store in a tightly closed container. Keep container closed when not in use.

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