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2,4,5-Trichlorophenoxyacetic acid

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Name

2,4,5-Trichlorophenoxyacetic acid

EINECS 202-273-3
CAS No. 93-76-5 Density 1.592 g/cm3
PSA 46.53000 LogP 3.11020
Solubility N/A Melting Point 154-158 °C(lit.)
Formula C8H5Cl3O3 Boiling Point 376.3 °C at 760 mmHg
Molecular Weight 255.485 Flash Point 181.4 °C
Transport Information UN 2811 6.1/PG 3 Appearance white to light tan odourless solid
Safety 24-60-61-36/37-26 Risk Codes 22-36/37/38-50/53-36-20/21/22-11
Molecular Structure Molecular Structure of 93-76-5 ((2,4,5-Trichlorophenoxy)acetic acid) Hazard Symbols HarmfulXn,DangerousN,FlammableF
Synonyms

Aceticacid, (2,4,5-trichlorophenoxy)- (8CI,9CI);(2,4,5-Trichlorophenoxy)acetic acid;2,4,5-T;Arbokan;BCF-Bushkiller;Forst U 46;Fortex;NSC 430;Trichlorophenoxyacetic acid;Trioxon;Verton 2T;

Article Data 17

2,4,5-Trichlorophenoxyacetic acid Chemical Properties

IUPAC Name: 2-(2,4,5-Trichlorophenoxy)acetic acid
Product Name: 2,4,5-Trichlorophenoxyacetic acid
The MF of 2-(2,4,5-Trichlorophenoxy)acetic acid (CAS NO.93-76-5) is C8H5Cl3O3.

                                      
The MW of 2-(2,4,5-Trichlorophenoxy)acetic acid (CAS NO.93-76-5) is 255.48.
Synonyms of 2-(2,4,5-Trichlorophenoxy)acetic acid (CAS NO.93-76-5): (2,4,5-Trichloor-fenoxy)-azijnzuur ; (2,4,5-Trichloor-fenoxy)-azijnzuur[qr] ; (2,4,5-Trichlorophenoxy)-aceticacid ; (2,4,5-Trichlor-phenoxy)-essigsaeure ; (2,4,5-Trichlor-phenoxy)-essigsaeure[qr] ; 2,4,5-Trichlorophenoxyacetic acid ; 2,4,5-Trichlorophenoxyacetica
Product Categories: Method Specific;Oeko-Tex Standard 100;PesticidesAlphabetic;TA - TE
Stability: Stable. Incompatible with strong bases, strong oxidizing agents, alkali metals, amines, alcohols. Reacts with many common metals
white to light tan odourless solid
Index of Refraction: 1.585 
EINECS: 202-273-3
Density: 1.592 g/ml 
Flash Point: 181.4 °C
Boiling Point: 376.3 °C
Melting Point: 154-158 °C
Storage temp: 0-6 °C
Merck: 13,9111

2,4,5-Trichlorophenoxyacetic acid Uses

   2-(2,4,5-Trichlorophenoxy)acetic acid (CAS NO.93-76-5) is to defoliate broad-leafed plants.

2,4,5-Trichlorophenoxyacetic acid Toxicity Data With Reference

1.    

mmo-bcs 1 nmol/plate

    MSERDS    Microbiology Series. 5 (1981),93.
2.    

cyt-grb-ipr 250 mg/kg

    MUREAV    Mutation Research. 65 (1979),83.
3.    

orl-rat TDLo:6 mg/kg (female 8D post):REP

    EXPEAM    Experientia. 39 (1983),891.
4.    

orl-rat TDLo:100 mg/kg (female 11D post):TER

    BEXBAN    Bulletin of Experimental Biology and Medicine. Translation of BEBMAE. 76 (1973),831.
5.    

orl-mus TDLo:3379 mg/kg/33W-C:NEO

    BJCAAI    British Journal of Cancer. 33 (1976),626.
6.    

scu-mus TDLo:215 mg/kg:ETA

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB223-159 .
7.    

orl-rat LD50:300 mg/kg

    RREVAH    Residue Reviews. 10 (1965),97.
8.    

skn-rat LD50:1535 mg/kg

    FAATDF    Fundamental and Applied Toxicology. 7 (1986),299.
9.    

orl-mus LD50:242 mg/kg

    RPZHAW    Roczniki Panstwowego Zakladu Higieny. 31 (1980),373.
10.    

orl-dog LD50:100 mg/kg

    PAREAQ    Pharmacological Reviews. 14 (1962),225.

2,4,5-Trichlorophenoxyacetic acid Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 156.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 ,1977,p. 273.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate

 

1.    

Evidence ; Human Limited Evidence . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

    IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 15 ,1977,p. 273.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 41 ,1986,p. 357.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)

 
 

Standards and Recommendations:

 

OSHA PEL: TWA 10 mg/m3

 

ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen

 

DFG MAK: 10 mg/m3

2,4,5-Trichlorophenoxyacetic acid Safety Profile

Poison by ingestion. Moderately toxic by skin contact. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Experimental reproductive effects. Mutation data reported. A highly toxic chlorinated phenoxy acid herbicide that is rapidly excreted after ingestion. Readily absorbed by inhalation and ingestion routes, slowly by skin contact. Signs of intoxication include weakness, lethargy, anorexia, diarrhea, ventricular fibrillation and/or cardiac arrest, and death. The teratogenicity is due in part to 2,3,7,8-TCDD, which is present as a contaminant (ARENAA 17,123,72). When heated to decomposition it emits toxic fumes of Cl. See also TCDD and CHLOROPHENOLS.Safety information of 2-(2,4,5-Trichlorophenoxy)acetic acid (CAS NO.93-76-5):
Hazard Codes  HarmfulXn,DangerousN,FlammableF
Risk Statements 
36/37/38 Irritating to eyes, respiratory system and skin
50/53 Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
11 Highly Flammable
Safety Statements 
24 Avoid contact with skin
60 This material and/or its container must be disposed of as hazardous waste
61 Avoid release to the environment. Refer to special instructions safety data sheet
36/37 Wear suitable protective clothing and gloves
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  AJ8400000
HazardClass  6.1(b)
PackingGroup  III

2,4,5-Trichlorophenoxyacetic acid Standards and Recommendations

OSHA PEL: TWA 10 mg/m3
ACGIH TLV: TWA 10 mg/m3; Not Classifiable as a Human Carcinogen
DFG MAK: 10 mg/m3

2,4,5-Trichlorophenoxyacetic acid Analytical Methods

For occupational chemical analysis use NIOSH: 2,4-D and 2,4,5-T, 5001.

2,4,5-Trichlorophenoxyacetic acid Specification

 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) , a synthetic auxin, is a chlorophenoxy acetic acid herbicide used to defoliate broad-leafed plants. It was developed in the late 1940s and was widely used in the agricultural industry until being phased out, starting in the late 1970s due to toxicity concerns. Agent Orange, a defoliant used by the U.S. in the Vietnam War, was equal parts 2,4,5-T and 2,4-D. 2,4,5-Trichlorophenoxyacetic acid is a weak acid. Reacts with organic and inorganic bases to form water-soluble salts and with alcohols to form esters. Incompatible with strong oxidizing agents and strong bases. Can corrode metals, especially if moist. May harm painted surfaces .

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