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2,6-Dimethyl-4-hydroxypyridine

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Name

2,6-Dimethyl-4-hydroxypyridine

EINECS 237-089-2
CAS No. 13603-44-6 Density 1.013 g/cm3
PSA 33.12000 LogP 1.40400
Solubility N/A Melting Point 230-232 °C
Formula C7H9NO Boiling Point 205.4 °C at 760 mm
Molecular Weight 123.155 Flash Point 93.1 °C
Transport Information N/A Appearance yellow to brown cryst
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 13603-44-6 (4-Hydroxy-2,6-dimethylpyridine) Hazard Symbols IrritantXi
Synonyms

2,6-Dimethyl-4-pyridinol;4-Hydroxy-2,6-dimethylpyridine;4-Hydroxy-2,6-lutidine;NSC 111932;

Article Data 24

2,6-Dimethyl-4-hydroxypyridine Synthetic route

520-45-6

Dehydracetic acid

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With ammonia In water at 120℃; for 0.333333h; Microwave irradiation;100%
With ammonia In water at 120℃; for 0.333333h; Microwave irradiation;100%
With ammonia In water at 120℃; for 0.333333h; microwave irradiation;100%
5093-70-9

4-bromo-2,6-dimethylpyridine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With syn-benzaldehyde oxime; N1,N2-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(l) chloride In dimethyl sulfoxide at 80℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;50%
1004-36-0

2,6-dimethylpyrone

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With ammonium hydroxide at 100℃;
With ammonia at 25℃;
With ammonium hydroxide
3512-75-2

4-chloro-2,6-lutidine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With sodium acetate; acetic acid at 200℃; Erhitzen des Reaktionsprodukts mit wss.Salzsaeure;
3512-80-9

4-amino-2,6-lutidine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With sulfuric acid; water; sodium nitrite
70271-80-6

ethyl 4-chloro-2,6-dimethylnicotinate

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With hydrogenchloride at 150℃;
358-23-6

trifluoromethylsulfonic anhydride

13603-44-6

2,6-dimethylpyridin-4-ol

129558-60-7

trifluoromethanesulfonic acid 2,6-dimethylpyridin-4-yl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;100%
Stage #1: 2,6-dimethylpyridin-4-ol With triethylamine In dichloromethane at 0℃; for 0.166667h;
Stage #2: trifluoromethylsulfonic anhydride; dmap In dichloromethane at 20℃; for 6h;
79%
13603-44-6

2,6-dimethylpyridin-4-ol

3,5-dibromo-2,6-dimethylpyridin-4-ol hydrobromide

Conditions
ConditionsYield
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Temperature; Reagent/catalyst;96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h;96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Reagent/catalyst; Temperature;96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Concentration; Reagent/catalyst; Temperature;96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Concentration; Reagent/catalyst; Temperature;96%
13603-44-6

2,6-dimethylpyridin-4-ol

3,5-dibromo-2,6-dimethylpyridin-4-ol hydrobromide

Conditions
ConditionsYield
With bromine; tert-butylamine In methanol; dichloromethane at 20℃; for 2.66667h;96%
With diisobutylamine; bromine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Reagent/catalyst;96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h;96%
13603-44-6

2,6-dimethylpyridin-4-ol

4563-28-4

3,5-dibromo-2,6-dimethylpyridin-4-ol

Conditions
ConditionsYield
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Temperature;96%
With 4-methyl-morpholine; bromine In methanol; dichloromethane at 20℃; for 2h;88%
With 4-methyl-morpholine; bromine In methanol; dichloromethane at 20℃; for 2h; Reagent/catalyst; Temperature; Cooling with ice;88%

2,6-Dimethyl-4-hydroxypyridine Chemical Properties

Molecular Formula: C7H9NO
Formula Weight: 123.15
mp of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 230-232°C
bp of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 351 °C
Flash Point: 93.1 °
density of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 1,053g/cm3
Vapour Pressure: 0.251 mmHg at 25°
refractive index : 1,501-1,503
Appearence of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): Yellow to Brown Crystal

2,6-Dimethyl-4-hydroxypyridine Toxicity Data With Reference

To the best of our knowledge, the toxicological properties of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6) have not been fully determined.
ACUTE EFFECTS: Irritant; May be harmful by ingestion and inhalation; Material is irritating to mucous membranes and upper respiratory tract.

2,6-Dimethyl-4-hydroxypyridine Safety Profile

Hazard Codes : Xi (Irritant)
Risk Statements : 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements : 26-36 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing)
Hazard Note : Irritant

2,6-Dimethyl-4-hydroxypyridine Specification

HANDLING AND STORAGE: Keep container tightly closed. Store in a cool, dry, well-ventilated area. Avoid sources of ignition. Do not breathe dust or vapor. Do not get in eyes, on skin, on clothing. Have safety shower and eye wash available. Ensure adequate ventilation during use. Use only in a chemical fume hood.
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