1-Propanol,2-amino-2-methyl-

2-AMINO-2-METHYL-1-PROPANOL(AMP) was collected on the same media used in OSHA Method 60, for diethylene triamine, so those extraction and analytical parameters were used as a starting point for AMP. The AMP was found to readily derivatize with the NITC to form a stable derivative. The samples were extracted with N,N-dimethylformamide (DMF), with a desorption efficiency mean of 100% for the concentration range of 224 to 11.2 μg/tube. The storage study showed no loss for samples stored for up to 14 days under both refrigerated and ambient conditions.

Partially evaluated method. This method has been subjected to established evaluation procedures of the Solvents Branch and is presented for information and trial use.

The CAS register number of 2-Amino-2-methyl-1-propanol is 124-68-5. It also can be called as 1-Propanol, 2-amino-2-methyl- and the IUPAC name about this chemical is 2-amino-2-methylpropan-1-ol. The molecular formula about this chemical is C₄H₁₁NO and the molecular weight is 89.14. It belongs to the following product categories, such as Industrial/Fine Chemicals; Chemical Amines; Aliphatics; Amines and so on. This chemical is stable and combustible. It incompatibles with strong oxidizing agents and it may present an explosion hazard if heated. This chemical can be used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.

Physical properties about 2-Amino-2-methyl-1-propanol are: (1)ACD/LogD (pH 5.5): -3.7; (2)ACD/LogD (pH 7.4): -3.1; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 2; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 46.25Ų; (11)Index of Refraction: 1.447; (12)Molar Refractivity: 25.61 cm³; (13)Molar Volume: 95.7 cm³; (14)Polarizability: 10.15x10^-24cm³; (15)Surface Tension: 34.4 dyne/cm; (16)Enthalpy of Vaporization: 47.01 kJ/mol; (17)Boiling Point: 167.2 °C at 760 mmHg; (18)Vapour Pressure: 0.566 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-methyl-2-nitro-propan-1-ol, this reaction can also produce b-hydroxyamino-isobutyl alcohol. This reaction will need reagent citrate buffer (pH 4.2), KCl and solvent ethanol. The reaction temperature of 30 ℃. The yield is about 25%. This reaction also need cotrolled potential electrolysis, cathod: Hg, vs. S.C.E.

Uses of 2-Amino-2-methyl-1-propanol: it can be used to produce 2-(2-hydroxy-ethylamino)-2-methyl-propan-1-o. This reaction will need reagent water.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes and skin and it is harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. When you are using it, you need avoid release to the environment. Refer to special instructions / safety data sheets.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(CO)N
(2)InChI: InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
(3)InChIKey: CBTVGIZVANVGBH-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2150mg/kg (2150mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LD50	oral	2900mg/kg (2900mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.