Ethanol,2-butoxy-

Reported in EPA TSCA Inventory. Glycol ethers are on the Community Right-To-Know List.

OSHA PEL: TWA 25 ppm (skin)
ACGIH TLV: 20 ppm (skin); Confirmed Animal Carcinogen.
DFG MAK: 20 ppm (98 mg/m³)
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD

For occupational chemical analysis use NIOSH: Alcohols IV, 1403.

The 2-Butoxyethanol is an organic solvent with the formula BuOC₂H₄OH (Bu = CH₃CH₂CH₂CH₂). It belongs to the product categories of Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols. Its EINECS registry number is 203-905-0. With the CAS registry number 111-76-2, its IUPAC name is called 2-butoxyethanol. This chemical's classification codes are Human Data; Mutation Data; Reproductive Effect; Skin / Eye Irritant; Tumor Data. It is a colorless liquid with a sweet, ether-like odour. 

Physical properties of 2-Butoxyethanol: (1)ACD/LogP: 0.80; (2)ACD/LogD (pH 5.5): 0.8; (3)ACD/LogD (pH 7.4): 0.8; (4)ACD/BCF (pH 5.5): 2.37; (5)ACD/BCF (pH 7.4): 2.37; (6)ACD/KOC (pH 5.5): 64.62; (7)ACD/KOC (pH 7.4): 64.62; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.418; (12)Molar Refractivity: 33.12 cm³; (13)Molar Volume: 131.4 cm³; (14)Surface Tension: 29.8 dyne/cm; (15)Density: 0.899 g/cm³; (16)Flash Point: 60 °C; (17)Enthalpy of Vaporization: 47.06 kJ/mol; (18)Boiling Point: 167.7 °C at 760 mmHg; (19)Vapour Pressure: 0.552 mmHg at 25°C.

Preparation: 2-Butoxyethanol is produced by monoethoxylation of butanol. In 2006, the total European production of all butyl glycol ethers amounted to 181 kilotons per annum (kt/a), approximately 50% (90 kt/a) of which was 2-butoxyethanol. World production is estimated to be 200 to 500 kt/a, of which 75% is for paints and coatings.

C₂H₄O + BuOH → BuOC₂H₄OH

Uses: 2-Butoxyethanol is a solvent in paints and surface coatings, as well as cleaning products and inks. Other products that contain 2-butoxyethanol include acrylic resin formulations, asphalt release agents, firefighting foam, leather protectors, oil spill dispersants, degreaser applications, and photographic strip solutions. Other products containing 2-butoxyethanol as a primary ingredient include some whiteboard cleaners, liquid soaps, cosmetics, dry cleaning solutions, lacquers, varnishes, herbicides, and latex paints. It is the main ingredient of many home, commercial and industrial cleaning solutions.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCCCOCCO
(2)InChI: InChI=1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3
(3)InChIKey: POAOYUHQDCAZBD-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LC	inhalation	> 633ppm/1H (633ppm)		National Technical Information Service. Vol. OTS0572613,
guinea pig	LD50	oral	1200mg/kg (1200mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig	LD50	skin	230uL/kg (0.23mL/kg)		Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965.
human	TCLo	inhalation	100ppm (100ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 50, 1974.
human	TCLo	inhalation	195ppm/8H (195ppm)	GASTROINTESTINAL: NAUSEA OR VOMITING	AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mammal (species unspecified)	LD50	unreported	1500mg/kg (1500mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse	LC50	inhalation	700ppm/7H (700ppm)	BEHAVIORAL: ANALGESIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: HEMATURIA	Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.
mouse	LD50	intraperitoneal	536mg/kg (536mg/kg)		Shell Chemical Company. Unpublished Report. Vol. -, Pg. 2, 1961.
mouse	LD50	intravenous	1130mg/kg (1130mg/kg)		AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mouse	LD50	oral	1230mg/kg (1230mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mouse	LD50	unreported	1050mg/kg (1050mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(11), Pg. 7, 1976.
mouse	LDLo	subcutaneous	500mg/kg (500mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.
rabbit	LD50	intraperitoneal	220mg/kg (220mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 67, 1982.
rabbit	LD50	intravenous	252mg/kg (252mg/kg)		AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rabbit	LD50	oral	300mg/kg (300mg/kg)		Yakkyoku. Pharmacy. Vol. 32, Pg. 1241, 1981.
rabbit	LD50	skin	220mg/kg (220mg/kg)		Dow Chemical Company Reports. Vol. MSD-46,
rat	LC50	inhalation	450ppm/4H (450ppm)	BEHAVIORAL: ATAXIA	Toxicology and Applied Pharmacology. Vol. 68, Pg. 405, 1983.
rat	LD50	intraperitoneal	220mg/kg (220mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 67, 1982.
rat	LD50	intravenous	307mg/kg (307mg/kg)		AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rat	LD50	oral	470mg/kg (470mg/kg)		Dow Chemical Company Reports. Vol. MSD-46,
rat	LD50	unreported	917mg/kg (917mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(11), Pg. 7, 1976.
women	TDLo	oral	7813uL/kg (7.813mL/kg)	BEHAVIORAL: COMA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Human Toxicology. Vol. 8, Pg. 243, 1989.
women	TDLo	oral	600mg/kg (600mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Human Toxicology. Vol. 7, Pg. 187, 1988.