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Cas Database |
| Name |
2-Chloro-3-bromo-5-aminopyridine |
EINECS | N/A |
| CAS No. | 130284-53-6 | Density | 1.835 g/cm3 |
| PSA | 38.91000 | LogP | 2.66090 |
| Solubility | N/A | Melting Point |
120-122 °C |
| Formula | C5H4BrClN2 | Boiling Point | 336.729 °C at 760 mmHg |
| Molecular Weight | 207.457 | Flash Point | 157.4 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-45 | Risk Codes |
 Xi:; |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
3-Amino-5-bromo-6-chloropyridine;5-Amino-3-bromo-2-chloropyridine; |
Article Data | 3 |
2-Chloro-3-bromo-5-aminopyridine Synthetic route
- 5470-17-7
3-bromo-2-chloro-5-nitropyridine
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
| Conditions | Yield |
|---|---|
| With hydrogen In tetrahydrofuran at 37℃; under 2250.23 Torr; for 18h; chemoselective reaction; | 92% |
| With iron; acetic acid In water for 2h; below 50 deg C; | 87% |
| With ammonium chloride; zinc In methanol at 90℃; for 2h; | 70.6% |
- 15862-33-6
3-bromo-2-hydroxy-5-nitropyridine
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 94 percent / POCl3, quinoline / 2 h / 120 °C 2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme |
- 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
- 1378034-59-3
5-bromo-6-chloro-N-((tetrahydro-2H-pyran-4-yl)methyl)pyridin-3-amine
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 20h; | 97% |
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
| Conditions | Yield |
|---|---|
| Stage #1: 5-amino-3-bromo-2-chloropyridine With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Sandmeyer Reaction; Stage #2: In water at 0 - 20℃; Sandmeyer Reaction; | 89% |
- 7486-35-3
tri-n-butyl(vinyl)tin
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); lithium chloride In 1,4-dioxane for 24h; Reflux; | 89% |
- 100-43-6
4-vinylpyridine
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
- 552330-65-1
6-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-amine
| Conditions | Yield |
|---|---|
| With triethylamine; tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; for 15h; | 84% |
| With tris(dibenzylideneacetone)dipalladium (0); triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; for 15h; |
- 100-43-6
4-vinylpyridine
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
- 6163-58-2
tris-(o-tolyl)phosphine
- 552330-65-1
6-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-amine
| Conditions | Yield |
|---|---|
| With triethylamine; tris-(dibenzylideneacetone)dipalladium(0) In ethyl acetate; N,N-dimethyl-formamide | 84% |
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
- 82689-14-3
N-tert-butyloxycarbonyl-tryptophanal
- 864773-87-5
1,1-dimethylethyl [(1S)-2-[(5-bromo-6-chloro-3-pyridinyl)amino]-1-(1H-indol-3-ylmethyl)ethyl]carbamate
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; | 75% |
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
| Conditions | Yield |
|---|---|
| Stage #1: Phe-COOH With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran for 2h; Heating / reflux; Stage #2: 5-amino-3-bromo-2-chloropyridine In tetrahydrofuran for 1h; Heating / reflux; | 59.4% |
- 104-53-0
3-phenyl-propionaldehyde
- 130284-53-6
2-chloro-3-bromo-5-aminopyridine
- 864773-02-4
5-bromo-6-chloro-N-(3-phenylpropyl)-3-pyridinamine
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 1h; | 50% |
2-Chloro-3-bromo-5-aminopyridine Specification
The 5-Amino-3-bromo-2-chloropyridine is an organic compound with the formula C5H4BrClN2. The IUPAC name of this chemical is 5-bromo-6-chloropyridin-3-amine. With the CAS registry number 130284-53-6, it is also named as 2-Chloro-3-bromo-5-aminopyridine. The product's categories are Pyridine; Pyridines; Boronic Acid. In addition, the molecular weight is 207.46.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.98; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 28; (6)ACD/BCF (pH 7.4): 28; (7)ACD/KOC (pH 5.5): 377; (8)ACD/KOC (pH 7.4): 377; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 38.91 Å2; (13)Index of Refraction: 1.648; (14)Molar Refractivity: 41.165 cm3; (15)Molar Volume: 113.073 cm3; (16)Surface Tension: 59.181 dyne/cm; (17)Enthalpy of Vaporization: 57.991 kJ/mol; (18)Vapour Pressure: 0 mmHg at 25°C; (19)Exact Mass: 205.924638; (20)MonoIsotopic Mass: 205.924638; (21)Topological Polar Surface Area: 38.9; (22)Heavy Atom Count: 9; (23)Complexity: 101.
People can use the following data to convert to the molecule structure.
1. SMILES:Nc1cnc(Cl)c(Br)c1
2. InChI:InChI=1/C5H4BrClN2/c6-4-1-3(8)2-9-5(4)7/h1-2H,8H2
3. InChIKey:ISKBXMMELYRESC-UHFFFAOYAZ
4. Std. InChI:InChI=1S/C5H4BrClN2/c6-4-1-3(8)2-9-5(4)7/h1-2H,8H2
5. Std. InChIKey:ISKBXMMELYRESC-UHFFFAOYSA-N
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