- 2-Chloro-4-methylquinoline
- 2-Chloro-4-methylquinoline-3-carbonitrile
- 6344-79-23-Pyridinecarboxylicacid, 4-methyl-, ethyl ester, 1-oxide
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Cas Database |
| Name |
2-Chloro-4-methylquinoline |
EINECS | 211-209-3 |
| CAS No. | 634-47-9 | Density | 1.225 g/cm3 |
| PSA | 12.89000 | LogP | 3.19660 |
| Solubility | N/A | Melting Point |
55-58 °C(lit.) |
| Formula | C10H8ClN | Boiling Point | 296 °C at 760 mmHg |
| Molecular Weight | 177.633 | Flash Point | 158.2 °C |
| Transport Information | N/A | Appearance | white to light yellow crystal powder |
| Safety | 26-37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Lepidine,2-chloro- (6CI,7CI,8CI);2-Chloro-4-methylquinoline;2-Chlorolepidine;NSC96476; |
Article Data | 21 |
2-Chloro-4-methylquinoline Synthetic route
| Conditions | Yield |
|---|---|
| With trichlorophosphate In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere; regioselective reaction; | 81% |
- 634-47-9
2-chloro-4-methylquinoline
| Conditions | Yield |
|---|---|
| With lithium chloride In 1,4-dioxane at 80℃; for 72h; Inert atmosphere; Sealed tube; regioselective reaction; | 32% |
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride; trichlorophosphate for 24h; Chlorination; Heating; | 96% |
| With trichlorophosphate for 10h; Heating; | 82% |
| With phosphorus pentachloride; trichlorophosphate |
- 10286-18-7
2-Chloro-4-methylquinoline 1-oxide
- 634-47-9
2-chloro-4-methylquinoline
| Conditions | Yield |
|---|---|
| With tris(bipyridine)ruthenium(II) dichloride hexahydrate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Irradiation; chemoselective reaction; | 82% |
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride; trichlorophosphate at 135 - 140℃; | |
| With phosphorus pentachloride; benzoyl chloride at 250℃; | |
| With ((1,3,5-triazine-2,4,6-triyl)tris(oxy))tris(triphenylphosphonium) chloride In neat (no solvent) at 140 - 150℃; for 2h; | |
| With trichlorophosphate at 120℃; for 2h; |
- 634-47-9
2-chloro-4-methylquinoline
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 80 - 85℃; |
| Conditions | Yield |
|---|---|
| With zinc dibromide In tetrahydrofuran |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sulfuric acid / 1 h / 100 °C 2: trichlorophosphate / 2 h / 120 °C View Scheme | |
| Multi-step reaction with 2 steps 1: Polyphosphoric acid / 130 - 140 °C 2: trichlorophosphate; pyridine / 80 - 90 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: 0.07 h / microwave irradiation 1.2: H2SO4 / 0.08 h / microwave irradiation 2.1: 82 percent / POCl3 / 10 h / Heating View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 3 h / 185 °C 2: sulfuric acid / 1 h / 100 °C 3: trichlorophosphate / 2 h / 120 °C View Scheme |
2-Chloro-4-methylquinoline Chemical Properties
Molecular Structure:
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Molecular Formula: C10H8ClN
Molecular Weight: 177.6302
IUPAC Name: 2-Chloro-4-methylquinoline
Synonyms of Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9): 2-Chloro-4-methylquinoline ; 2-Chlorolepidine ; EINECS 211-209-3 ; NSC 96476 ; Lepidine, 2-chloro- (8CI) ; Quinoline, 2-chloro-4-methyl- (9CI)
CAS NO: 634-47-9
Classification Code: Quinoline&Isoquinoline ; Alkylquinolines ; Haloquinolines ; Quinolines
Melting point: 55-58 °C
Index of Refraction: 1.634
Molar Refractivity: 51.9 cm3
Molar Volume: 144.9 cm3
Surface Tension: 46.5 dyne/cm
Density: 1.225 g/cm3
Flash Point: 158.2 °C
Enthalpy of Vaporization: 51.43 kJ/mol
Boiling Point: 296 °C at 760 mmHg
Vapour Pressure: 0.0026 mmHg at 25°C
2-Chloro-4-methylquinoline Uses
Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9) is used in organic synthesis.
2-Chloro-4-methylquinoline Safety Profile
Hazard Codes of Quinoline,2-chloro-4-methyl- (CAS NO.634-47-9): 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
S36: Wear suitable protective clothing.
WGK Germany: 3
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