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Cas Database |
| Name |
2-Hydroxy-3-naphtoamide |
EINECS | 222-926-6 |
| CAS No. | 3665-51-8 | Density | 1.33g/cm3 |
| PSA | 63.32000 | LogP | 2.34460 |
| Solubility | N/A | Melting Point |
211-216 ºC |
| Formula | C11H9 N O2 | Boiling Point | 426.4°Cat760mmHg |
| Molecular Weight | 187.198 | Flash Point | 211.7°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | R36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
2-Naphthamide,3-hydroxy- (6CI,7CI,8CI); 2-Hydroxy-3-naphthalenecarboxamide;2-Hydroxy-3-naphthamide; 2-Hydroxy-3-naphthoamide; 2-Hydroxy-3-naphthoic acidamide; 3-Hydroxy-2-naphthalenecarboxamide; 3-Hydroxy-2-naphthamide; NSC 37060 |
Article Data | 16 |
2-Hydroxy-3-naphtoamide Synthetic route
- 53855-64-4
3-acetoxy-2-naphthoyl chloride
- 3665-51-8
3-hydroxy-2-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
| With ammonium hydroxide In dichloromethane for 24h; Ambient temperature; | 95% |
| Conditions | Yield |
|---|---|
| With phosphoric acid; urea at 180℃; for 2h; | 90% |
| With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 1h; | 72% |
| Multi-step reaction with 2 steps 1: HCl 2: alcoholic ammonia / 170 °C / im geschlossenen Rohr View Scheme | |
| Multi-step reaction with 5 steps 1: concentrated sulfuric acid 2: thionyl chloride; benzene / Einleiten von Ammoniak in das Reaktionsgemisch 3: thionyl chloride 4: methanolic KOH-solution 5: concentrated sulfuric acid / 0 °C View Scheme |
- 52449-77-1
3-hydroxy-2-naphthonitrile
- 3665-51-8
3-hydroxy-2-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
| With sulfuric acid at 0℃; |
| Conditions | Yield |
|---|---|
| With ammonia at 170℃; im geschlossenen Rohr; | |
| With ammonium sulfite; ammonia at 125℃; im geschlossenen Rohr; |
| Conditions | Yield |
|---|---|
| With ammonia; benzene |
- 13042-06-3
3-methoxy-[2]naphthoic acid amide
- 3665-51-8
3-hydroxy-2-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
| With hydrogen bromide; acetic acid |
- 92616-44-9
3-methoxy-2-naphthonitrile
- 3665-51-8
3-hydroxy-2-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
| With hydrogen bromide; acetic acid |
| Conditions | Yield |
|---|---|
| With phosphoric acid |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 97 percent / oxalyl chloride, DMF / toluene / 1 h / Ambient temperature 2: 95 percent / conc. NH4OH / CH2Cl2 / 24 h / Ambient temperature View Scheme | |
| Multi-step reaction with 4 steps 1: thionyl chloride; benzene / Einleiten von Ammoniak in das Reaktionsgemisch 2: thionyl chloride 3: methanolic KOH-solution 4: concentrated sulfuric acid / 0 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 82 percent / conc. H2SO4 / 0.08 h / Heating 2: 97 percent / oxalyl chloride, DMF / toluene / 1 h / Ambient temperature 3: 95 percent / conc. NH4OH / CH2Cl2 / 24 h / Ambient temperature View Scheme |
2-Hydroxy-3-naphtoamide Chemical Properties
Molecular Formula: C11H9NO2
Molecular Weight: 187.20
EINECS: 222-926-6
Density: 1.33 g/cm3
Flash Point: 211.7 °C
Melting Point: 211-216 °C
Index of Refraction: 1.708
Appearance: ochre powder
CAS Registry Number: 3665-51-8
Enthalpy of Vaporization: 70.75 kJ/mol
Boiling Point: 426.4 °C at 760 mmHg
Vapour Pressure: 7.16E-08 mmHg at 25°C
IUPAC Name: 3-hydroxynaphthalene-2-carboxamide
Synonyms: 3-Hydroxy-2-Naphthalenecarboxamide ; 3-Hydroxy-2-naphthamid ; 3-Hydroxy-2-Naphtoamide ; 2-Hydroxy-3-naphthalenecarboxamide ; 3-Hydroxy-2-naphthoylamide ; 3-hydroxynaphthalene-2-carboxamide |
Following is the molecular structure of 3-Hydroxy-2-Naphtoamide (CAS NO.3665-51-8):
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2-Hydroxy-3-naphtoamide Uses
3-Hydroxy-2-Naphtoamide (CAS NO.3665-51-8) is used as a medicine, high-grade organic pigments, automotive paints, as well as dedicated an important intermediate of dye.
2-Hydroxy-3-naphtoamide Toxicity Data With Reference
| 1. | ipr-rat LD50:2000 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 108 (1953),450. |
2-Hydroxy-3-naphtoamide Consensus Reports
Reported in EPA TSCA Inventory.
2-Hydroxy-3-naphtoamide Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of 3-Hydroxy-2-Naphtoamide (CAS NO.3665-51-8):
Hazard Codes: Xi 
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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