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(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With L-glutamic acid; pyridoxal 5'-phosphate In water at 40℃; for 12h; E.coli Aspartate transaminase, pH 8; | 30% |
(E)-3-(2-methylphenyl)acrylic acid
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With carbon dioxide; Taxus chinensis phenylalanine aminomutase; ammonia In water pH=10; Kinetics; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; | |
With ammonia at 30℃; for 17h; pH=10; Time; Reagent/catalyst; | n/a |
2-([(18)F]-fluoromethyl)-L-phenylalanine
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With water at 50℃; pH=7; |
2-methylcinnamic acid
A
(S)-3-amino-3-(2-methylphenyl)propionic acid
B
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With ammonium bisulphate; EncP-E293M variant at 55℃; for 22h; pH=8.3; Enzymatic reaction; stereoselective reaction; | A n/a B n/a |
2-methylcinnamic acid
B
(S)-3-amino-3-(2-methylphenyl)propionic acid
C
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With ammonium bisulphate; EncP wild type enzyme at 55℃; for 22h; pH=8.3; Enzymatic reaction; stereoselective reaction; | A n/a B n/a C n/a |
3-amino-3-(2-methylphenyl)propanoic acid
B
(E)-3-(2-methylphenyl)acrylic acid
C
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With phenylalanine ammonia α-lyase from Anabaena variabilis; phenylalanine ammonia lyase from Streptomyces maritimus In aq. buffer at 30℃; for 24h; pH=8; Reagent/catalyst; Resolution of racemate; Enzymatic reaction; enantioselective reaction; |
(E)-3-(2-methylphenyl)acrylic acid
A
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
Stage #1: (E)-3-(2-methylphenyl)acrylic acid With ammonium hydroxide; phenylalanine ammonia-lyase from Anabaena variabilis N347A mutant In aq. buffer at 35℃; for 12h; pH=8.5; Stage #2: With borane-ammonia complex; L-amino acid deaminase from Proteus mirabilis In aq. buffer at 35℃; for 12h; pH=8.5; stereoselective reaction; | A n/a B n/a |
2-amino-3-(2-methylphenyl)propanoic acid
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phenylalanine ammonia-lyase from Pseudozyma antarctica yeast / aq. buffer / 168 h / 30 °C / pH 8.5 / Resolution of racemate 2: ammonia / 17 h / 30 °C / pH 10 View Scheme |
di-tert-butyl dicarbonate
(S)-2-amino-3-(o-tolyl)propanoic acid
Nα-tert-butyloxycarbonyl-2'-methyl-L-phenylalanine
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 20℃; for 2h; | 89.2% |
1,10-Phenanthroline
(S)-2-amino-3-(o-tolyl)propanoic acid
Conditions | Yield |
---|---|
With NaOH; HCl In hydrogenchloride; methanol addn. of 2 equiv. aminoacid to PdCl2 (in 1 M HCl), pH-adjustment to 6-7 (aq. NaOH), addn. of 1 equiv. phenanthroline (in aq. MeOH), stirring at 40°C overnight, pptn. on addn. of aq. NaClO4; | 89% |
The 2-Methylphenyl-L-alanine, also known as L-2-Methylphenylalanine, is the organic compound with the formula C10H13NO2. It belongs to the product categories of Amino Acids; Phenylalanine Analogs and Other Aromatic Alpha Amino Acids; Amino Acid Derivatives; a-Amino. With the CAS registry number 80126-53-0, its IUPAC name is called (2S)-2-amino-3-(2-methylphenyl)propanoic acid. When you are using this chemical, please be cautious about it. This chemical may cause inflammation to the skin or other mucous membranes. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides.
Physical properties of 2-Methylphenyl-L-alanine: (1)ACD/LogP: 1.57; (2)ACD/LogD (pH 5.5): -0.93; (3)ACD/LogD (pH 7.4): -0.93; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.568; (12)Molar Refractivity: 50.31 cm3; (13)Molar Volume: 153.7 cm3; (14)Surface Tension: 50.3 dyne/cm; (15)Density: 1.165 g/cm3; (16)Flash Point: 151.1 °C; (17)Enthalpy of Vaporization: 60 kJ/mol; (18)Boiling Point: 326.2 °C at 760 mmHg; (19)Vapour Pressure: 8.9E-05 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=CC=CC=C1CC(C(=O)O)N
(2)Isomeric SMILES: CC1=CC=CC=C1C[C@@H](C(=O)O)N
(3)InChI: InChI=1S/C10H13NO2/c1-7-4-2-3-5-8(7)6-9(11)10(12)13/h2-5,9H,6,11H2,1H3,(H,12,13)/t9-/m0/s1
(4)InChIKey: NHBKDLSKDKUGSB-VIFPVBQESA-N