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2-Methoxyestradiol
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Name

2-Methoxyestradiol

 EINECS N/A
CAS No. 362-07-2 Density 1.178 g/cm3
PSA 49.69000 LogP 3.61780
Solubility DMSO: 10 mg/mL Melting Point 188-190 °C
Formula C19H26O3 Boiling Point 464.4 °C at 760 mmHg
Molecular Weight 302.414 Flash Point 234.7 °C
Transport Information UN 3077 9/PG 3 Appearance Off-white solid
Safety 22-26-36/37/39-45-53-36 Risk Codes 23/24/25-36/37/38-48-61-60-46-45
Molecular Structure Molecular Structure of 362-07-2 (2-METHOXYESTRADIOL) Hazard Symbols ToxicT, IrritantXi
Synonyms

Estra-1,3,5(10)-triene-3,17b-diol, 2-methoxy- (7CI,8CI);Estradiol, 2-methoxy- (6CI);2-Hydroxyestradiol 2-methyl ether;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem;

Article Data 2

2-Methoxyestradiol Chemical Properties

Empirical Formula: C19H26O3
Molecular Weight: 302.4079 g/mol
Index of Refraction: 1.586
Density: 1.178 g/cm3
Flash Point: 234.7 °C
Enthalpy of Vaporization: 76.48 kJ/mol
Boiling Point: 464.4 °C at 760 mmHg
Vapour Pressure: 2E-09 mmHg at 25 °C
Melting point: 188-190 °C
Storage temp.: -20 4 °C
Appearance: Off-white solid
The structure of 2-Methoxyestradiol (CAS.362-07-2):
                             
IUPAC Name: (8R,9S,13S,14S,17S)-2-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O
Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
InChI: InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
InChIKey: CQOQDQWUFQDJMK-SSTWWWIQSA-N
Product Categories of 2-Methoxyestradiol (CAS.362-07-2): Intermediates & Fine Chemicals;Steroids;Metabolites & Impurities;Pharmaceuticals

2-Methoxyestradiol Uses

 2-Methoxyestradiol (CAS.362-07-2) is a natural metabolite which is devoid of estrogenic activity. It is inhibits cell proliferation and angiogenesis.

2-Methoxyestradiol Toxicity Data With Reference

1.    

mnt-ham-emb 300 µg/

     CRNGDP    Carcinogenesis. 21 (2000),735.
2.    

mor-ham-emb 100 µg/

     CRNGDP    Carcinogenesis. 21 (2000),735.
3.    

cyt-ham-emb 300 µg/

     CRNGDP    Carcinogenesis. 21 (2000),735.
4.    

sln-ham-emb 300 µg/

     CRNGDP    Carcinogenesis. 21 (2000),735.
5.    

msc-ham-emb 100 µg/

     CRNGDP    Carcinogenesis. 21 (2000),735.
6.    

mor-ham-emb 0.1 mg/L/48H

     CRNGDP    Carcinogenesis. 21 (2000),735.
7.    

cyt-ham-emb 0.3 mg/L/24H

     CRNGDP    Carcinogenesis. 21 (2000),735.

2-Methoxyestradiol Safety Profile

Mutation data reported. When heated to decomposition 2-Methoxyestradiol (CAS.362-07-2) emits acrid smoke and irritating vapors.
Hazard Codes: ToxicT,IrritantXi
Risk Statements: 23/24/25-36/37/38-48-61-60-46-45 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R60:May impair fertility. 
R61:May cause harm to the unborn child.
Safety Statements: 22-26-36/37/39-45-53-36 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use.

2-Methoxyestradiol Specification

 2-Methoxyestradiol ,its cas register number is 362-07-2. It also can be called Panzem ; 2-Hydroxyestradol 2-methyl ether ; and 2-Methoxyestradiol-17beta .

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