Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

2-Methyl-2-butanol
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

2-Methyl-2-butanol

 EINECS 200-908-9
CAS No. 75-85-4 Density 0.811 g/cm3
PSA 20.23000 LogP 1.16730
Solubility 120 g/L (20 °C) in water Melting Point -12 °C
Formula C5H12O Boiling Point 102 °C at 760 mmHg
Molecular Weight 88.1497 Flash Point 21.1 °C
Transport Information UN 1105 3/PG 2 Appearance colourless liquid with a camphor-like odour
Safety 46 Risk Codes 11-20-37/38
Molecular Structure Molecular Structure of 75-85-4 (tert-Amyl alcohol) Hazard Symbols FlammableF,HarmfulXn
Synonyms

tert-Pentylalcohol (8CI);1,1-Dimethyl-1-propanol;2-Ethyl-2-propanol;2-Hydroxy-2-methylbutane;2-Methyl-2-hydroxybutane;Amylenehydrate;Dimethylethylcarbinol;Ethyldimethylcarbinol;NSC 25498;tert-Amylalcohol;tert-Pentanol;

Article Data 199

2-Methyl-2-butanol Synthetic route

115-19-5

2-methyl-but-3-yn-2-ol

A

75-85-4

tert-Amyl alcohol

B

115-18-4

2-methyl-3-buten-2-ol

Conditions
ConditionsYield
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics;A n/a
B 98%
With hydrogen; palladium dichloride In N,N-dimethyl-formamide under 18751.5 Torr; for 0.3h; Product distribution; Ambient temperature; various time;A 2%
B 91%
With hydrogen; nickel dihydroxide; Ni(C17H35COO)2 In toluene at 40℃; Product distribution; Kinetics; other catalyst. Object of study: selectivity;A 41.6%
B 85.5%
115-19-5

2-methyl-but-3-yn-2-ol

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With sodium tetrahydroborate; hydrogen; nickel dichloride In isopropyl alcohol at 60℃; under 760.051 Torr; for 7h;90%
With hydrogen; palladium membrane at 29.9℃; Kinetics; electrochemical reduction;
With alkali durch elektrolytische Reduktion an Platinkathoden;
6689-16-3

2-methyl-2-trimethylsiloxybutane

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.416667h; Green chemistry;80%
97-94-9

triethyl borane

67-64-1

acetone

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; N,N-dimethyl-formamide for 7h; Ambient temperature; electrolysis with Pt/Cu electrodes;76%
78-78-4

methylbutane

A

563-80-4

3-methyl-butan-2-one

B

75-85-4

tert-Amyl alcohol

C

96-17-3, 57456-98-1

2-Methylbutyraldehyde

D

598-75-4

3-methyl-2-butanol

Conditions
ConditionsYield
With [2,2]bipyridinyl; Ba; trifluoroacetic acid In dichloromethane at 20℃; for 0.0333333h;A 11%
B 70%
C 4.5%
D n/a
With [2,2]bipyridinyl; Ba; trifluoroacetic acid In dichloromethane at 20℃; for 0.0333333h; Product distribution;A 11%
B 70%
C 4.5%
D n/a
563-46-2

2-Methyl-1-butene

64-19-7

acetic acid

A

75-85-4

tert-Amyl alcohol

B

661-53-0

2-fluoro-2-methylbutane

C

625-16-1

tert-amyl acetate

Conditions
ConditionsYield
With hydrogenchloride; water at 25℃; Kinetics;A 70%
B 25%
C n/a
54269-84-0

1,1-dimethyl-1-(2-propenyloxy)-propane

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran for 8h; Ambient temperature;49%
78-78-4

methylbutane

A

75-85-4

tert-Amyl alcohol

B

64-19-7

acetic acid

C

67-64-1

acetone

Conditions
ConditionsYield
With N-hydroxyphthalimide; air; cobalt(II) acetate In benzonitrile at 100℃; under 7600 Torr; for 8h; Oxidation;A 21%
B 15%
C 32%
1927-66-8

2-(1,1-dimethyl-propoxy)-tetrahydropyran

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With acid-washed bentonite In acetone at 40 - 50℃;10%
558-30-5

2-methyl-1,2-epoxypropane

2999-74-8

dimethylmagnesium

75-85-4

tert-Amyl alcohol

Conditions
ConditionsYield
With diethyl ether

2-Methyl-2-butanol Specification

The IUPAC name of 2-Methyl-2-butanol is 2-methylbutan-2-ol. With the CAS registry number 75-85-4, it is also named as tert-Amyl alcohol. The product's category is Organics. Besides, it is colourless liquid with a camphor-like odour, which should be sealed in a cool, dark and ventilated place. It is light sensitive, and incompatible with strong oxidizing agents. In addition, its molecular formula is C5H12O and molecular weight is 88.15.

The other characteristics of this product can be summarized as: (1)EINECS: 200-908-9; (2)ACD/LogP: 1.04; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.04; (5)ACD/LogD (pH 7.4): 1.04; (6)ACD/BCF (pH 5.5): 3.64; (7)ACD/BCF (pH 7.4): 3.64; (8)ACD/KOC (pH 5.5): 87.73; (9)ACD/KOC (pH 7.4): 87.73; (10)#H bond acceptors: 1; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.406; (14)Molar Refractivity: 26.71 cm3; (15)Molar Volume: 108.6 cm3; (16)Surface Tension: 25 dyne/cm; (17)Density: 0.811 g/cm3; (18)Flash Point: 21.1 °C; (19)Melting point: -12 °C; (20)Water solubility: 120 g/L (20 °C); (21)Enthalpy of Vaporization: 39.77 kJ/mol; (22)Boiling Point: 102 °C at 760 mmHg; (23)Vapour Pressure: 19.2 mmHg at 25 °C.

Preparation of 2-Methyl-2-butanol: this chemical can be prepared by Acetone and Acetylene. This reaction will occur by ethynylation and hydrogenation.

Uses of 2-Methyl-2-butanol: this chemical possesses sedative, hypnotic, and anticonvulsant effects in humans. It is a cosolvent of cellulose esters, cellulose ethers, dope, varnish, mineral flotation agent, acridine and nitro spray. Moreover, it can react with Diketene to get Acetoacetic acid tert-pentyl ester.



This reaction needs 4-Dimethylaminopyridine and Tetrahydrofuran at temperature of 20 °C for 5 min. The yield is 73 %.

When you are using this chemical, please be cautious about it as the following: it is highly flammable. It is also harmful by inhalation. And it is irritating to respiratory system and skin. If swallowed, please seek medical advice immediately and show this container or label.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCC(C)(C)O
(2)InChI: InChI=1S/C5H12O/c1-4-5(2,3)6/h6H,4H2,1-3H3
(3)InChIKey: MSXVEPNJUHWQHW-UHFFFAOYSA-N 

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo parenteral 4gm/kg (4000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935.
man LDLo unreported 441mg/kg (441mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intravenous 610mg/kg (610mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962.
mouse LD50 subcutaneous 2100mg/kg (2100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 161, 1955.
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg)   Skandinavisches Archiv fuer Physiologie. Vol. 79, Pg. 258, 1938.
mouse LDLo oral 2500mg/kg (2500mg/kg)   "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LD50 oral 2028mg/kg (2028mg/kg) SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.
rat LCLo inhalation 5700ppm/6H (5700ppm) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0536478,
rat LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: ATAXIA Science. Vol. 116, Pg. 663, 1952.
rat LDLo intraperitoneal 1530mg/kg (1530mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 1, 1945.
rat LDLo rectal 1400mg/kg (1400mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 36, 1933.
rat LDLo subcutaneous 1400mg/kg (1400mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 36, 1933.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 75-85-4